Highly enantioselective catalytic conjugate addition of N-heterocycles to α,β-unsaturated ketones and imides

被引：134

作者：

Gandelman, M ^{[1
]}

Jacobsen, EN ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 16期

关键词：

aluminum; asymmetric catalysis; heterocycles; nucleobases; synthetic methods;

D O I：

10.1002/anie.200463058

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) New nucleophiles in the arena of asymmetric catalysis, fused and nonfused N-heterocycles undergo conjugate addition to unsaturated imides and enones in the presence of a chiral [(salen)Al III] complex with generally high enantioselectivities (see scheme; salen=N,N′-bis(salicylaldehydo)ethylenediamine). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2393 / 2397

页数：5

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