Cells, scaffolds, and molecules for myocardial tissue engineering

被引：235

作者：

Leor, J ^{[1
]}

Amsalem, Y

Cohen, S

机构：

[1] Tel Aviv Univ, Chaim Sheba Med Ctr, Neufeld Cardiac Res Inst, IL-52621 Tel Hashomer, Israel

[2] Ben Gurion Univ Negev, Dept Biotechnol Engn, IL-84105 Beer Sheva, Israel

来源：

PHARMACOLOGY & THERAPEUTICS | 2005年 / 105卷 / 02期

关键词：

biomaterial; cell; heart; scaffold; tissue engineering; transplantation;

D O I：

10.1016/j.pharmthera.2004.10.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Unlike heart valves or blood vessels. heart muscle has no replacement alternatives. The most challenging goal in the field of cardiovascular tissue engineering is the creation/ regeneration of an engineered heart muscle. Recent advances in methods of stem cell isolation, culture in bioreactors. and the synthesis of bioactive materials promise to create engineered cardiac tissue ex vivo. At the same time. new approaches arc conceived that explore ways to induce tissue regeneration after injury. The purpose of our review is to describe the principles status, and challenges of myocardial tissue engineering with emphasize on the concept of in situ cardiac tissue engineering and regeneration. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：151 / 163

页数：13

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