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B-arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice

被引：67
作者：
Bouxsein, ML
Pierroz, DD
Glatt, V
Goddard, DS
Cavat, F
Rizzoli, R
Ferrari, SL
机构：
[1] Beth Israel Deaconess Med Ctr, Orthoped Biomech Lab, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Univ Hosp Geneva, Serv Bone Dis, Dept Rehabil & Geriatr, Geneva, Switzerland
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 04期
关键词：
beta-arrestin; PTH; knockout; bone architecture; bone remodeling;
D O I：
10.1359/JBMR.041204
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cytoplasmic arrestins regulate PTH signaling in vitro. We show that female beta-arrestin2(-/-) mice have decreased bone mass and altered bone architecture. The effects of intermittent PTH administration on bone microarchitecture differed in beta-arrestin2(-/-) and wildtype mice. These data indicate that arrestin-mediated regulation of intracellular signaling contributes to the differential effects of PTH at endosteal and periosteal bone surfaces.
引用
收藏
页码：635 / 643
页数：9
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