Synthesis, self-assembly, and characterization of PEG-coated iron oxide nanoparticles as potential MRI contrast agent

被引：108

作者：

Chen Yue-Jian ^{[1
,2
]}

Tao Juan ^{[1
,2
]}

Xiong Fei ^{[2
]}

Zhu Jia-Bi ^{[1
]}

Gu Ning ^{[2
]}

Zhang Yi-Hua ^{[3
]}

Ding Ye ^{[3
]}

Ge Liang ^{[1
]}

机构：

[1] China Pharmaceut Univ, Pharmaceut Res Inst, Nanjing 210009, Peoples R China

[2] Southeast Univ, State Key Lab Bioelect, Jiangsu Lab Biomat & Devices, Sch Biol Sci & Med Engn, Nanjing, Peoples R China

[3] China Pharmaceut Univ, Ctr Drug Res, Nanjing 210009, Peoples R China

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2010年 / 36卷 / 10期

基金：

中国国家自然科学基金;

关键词：

CMC; magnetic nanoparticles; monodisperse; MRI; self-assembly; superparamagnetic iron oxide nanoparticles; thermal decomposition; MAGNETIC NANOPARTICLES; PARTICLE-SIZE; ACCUMULATION; NANOCRYSTALS; SPECTROSCOPY; BIOMEDICINE;

D O I：

10.3109/03639041003710151

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Aim: Investigated the self-assembly and characterization of novel antifouling polyethylene glycol (PEG)-coated iron oxide nanoparticles as nanoprobes for magnetic resonance imaging (MRI) contrast agent. Method: Monodisperse oleic acid-coated superparamagnetic iron oxide cores are synthesized by thermal decomposition of iron oleate. The self-assembly behavior between iron oxide cores and PEG-lipid conjugates in water and their characteristics are confirmed by transmission electron microscope, X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy, and vibrating sample magnetometer. Result: Dynamic light scattering shows superparamagnetic iron oxide nanoparticles coated with PEG are stable in water for pH of 3-10 and ionic strengths up to 0.3 M NaCl, and are protein resistant in physiological conditions. Additionally, in vitro MRI study demonstrates the efficient magnetic resonance imaging contrast characteristics of the iron oxide nanoparticles. Conclusion: The result indicates that the novel antifouling PEG-coated superparamagnetic iron oxide nanoparticles could potentially be used in a wide range of applications such as biotechnology, MRI, and magnetic fluid hyperthermia.

引用

页码：1235 / 1244

页数：10

共 40 条

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