Altered uric acid levels and disease states

被引：262

作者：

Kutzing, Melinda K. ^{[1
,2
]}

Firestein, Bonnie L. ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Cell Biol & Neurosci, Piscataway, NJ 08855 USA

[2] Rutgers State Univ, Grad Program Biomed Engn, Piscataway, NJ USA

来源：

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | 2008年 / 324卷 / 01期

关键词：

D O I：

10.1124/jpet.107.129031

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Altered serum uric acid concentrations, both above and below normal levels, have been linked to a number of disease states. An abnormally high uric acid level has been correlated with gout, hypertension, cardiovascular disease, and renal disease, whereas a reduced uric acid concentration has been linked to multiple sclerosis, Parkinson's disease, Alzheimer's disease, and optic neuritis. Historically, uric acid has been considered a marker of these disease states. Recent studies, however, have provided evidence that uric acid may actually play a role in the development or progression of such diseases. As a result, the manipulation of uric acid concentrations is now either included in, or being investigated for, the treatment of a variety of disease states.

引用

页码：1 / 7

页数：7

共 69 条

[41]

Lin KC, 2000, J RHEUMATOL, V27, P1501

[42] Secondary degeneration reduced by inosine after spinal cord injury in rats [J].

Liu, F. ;

You, S. -W. ;

Yao, L. -P. ;

Liu, H. -L. ;

Jiao, X. -Y. ;

Shi, M. ;

Zhao, Q. -B. ;

Ju, G. .

SPINAL CORD, 2006, 44 (07) :421-426

[43] Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism [J].

Mazzali, M ;

Hughes, J ;

Kim, YG ;

Jefferson, JA ;

Kang, DH ;

Gordon, KL ;

Lan, HY ;

Kivlighn, S ;

Johnson, RJ .

HYPERTENSION, 2001, 38 (05) :1101-1106

[44] SERUM URIC-ACID IN ESSENTIAL-HYPERTENSION - AN INDICATOR OF RENAL VASCULAR INVOLVEMENT [J].

MESSERLI, FH ;

FROHLICH, ED ;

DRESLINSKI, GR ;

SUAREZ, DH ;

ARISTIMUNO, GG .

ANNALS OF INTERNAL MEDICINE, 1980, 93 (06) :817-821

[45] Renal urate transport [J].

Mount, David B. ;

Kwon, Charles Y. ;

Zandi-Nejad, Kambiz .

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2006, 32 (02) :313-+

[46] Uric acid and serum antioxidant capacity: a reaction to atherosclerosis? [J].

Nieto, FJ ;

Iribarren, C ;

Gross, MD ;

Comstock, GW ;

Cutler, RG .

ATHEROSCLEROSIS, 2000, 148 (01) :131-139

[47] Nitric oxide and peroxynitrite in health and disease [J].

Pacher, Pal ;

Beckman, Joseph S. ;

Liaudet, Lucas .

PHYSIOLOGICAL REVIEWS, 2007, 87 (01) :315-424

[48] Uric acid and the state of the intrarenal renin-angiotensin system in humans [J].

Perlstein, TS ;

Gumieniak, O ;

Hopkins, PN ;

Murphey, LJ ;

Brown, NJ ;

Williams, GH ;

Hollenberg, NK ;

Fisher, NDL .

KIDNEY INTERNATIONAL, 2004, 66 (04) :1465-1470

[49] Salivary uric acid at the acidic pH of the stomach is the principal defense against nitrite-derived reactive species: Sparing effects of chlorogenic acid and serum albumin [J].

Pietraforte, Donatella ;

Castelli, Marco ;

Metere, Alessio ;

Scorza, Giuseppe ;

Samoggia, Paola ;

Menditto, Antonio ;

Minetti, Maurizio .

FREE RADICAL BIOLOGY AND MEDICINE, 2006, 41 (12) :1753-1763

[50] Uric acid as a cardiovascular risk factor in arterial hypertension [J].

Puig, JG ;

Ruilope, LM .

JOURNAL OF HYPERTENSION, 1999, 17 (07) :869-872

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