Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots

被引：19

作者：

Lee, WS

Kim, MJ

Beck, YI

Park, YD

Jeong, TS

机构：

[1] Korea Res Inst Biosci & Biotechnol, Natl Res Lab Lipid Metab & Atherosclerosis, Taejon 305333, South Korea

[2] Univ Sci & Technol, Taejon 305333, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 15期

关键词：

Lp-PLA(2) inhibitor; fatty acid glycerols; Saururus chinensis;

D O I：

10.1016/j.bmcl.2005.05.056

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

(R)-Glycerol-monolinoleate 4 and (R)-glycerol-monostearate 5 were isolated from the ethyl acetate extracts of Saururus chinensis roots and (R)- or (S)-fatty acid glycerols 4 and 5 were synthesized for confirming their structures and evaluating their inhibitory activities against Lp-PLA(2). The (R)-4 and (S)-4 exhibited Lp-PLA2 inhibitory activities with IC50 values of 45.0 and 52.0 mu M, respectively. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：3573 / 3575

页数：3

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