Proteins and cells on PEG immobilized silicon surfaces

被引：337

作者：

Zhang, MQ

Desai, T

Ferrari, M ^{[2
]}

机构：

[1] Univ Calif Berkeley, UCB UCSF Bioengn Joint Grad Grp, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Coll Engn, Biomed Microdevices Ctr, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Mat Sci & Min Engn, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Dept Civil & Environm Engn, Berkeley, CA 94720 USA

来源：

BIOMATERIALS | 1998年 / 19卷 / 10期

关键词：

silicon; PEG immobilization; protein adsorption; cellular interaction; ellipsometry;

D O I：

10.1016/S0142-9612(98)00026-X

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Silicon surfaces were modified by covalent attachment of a self-assembled (SA) polyethylene glycol (PEG) film. Adsorption of albumin, fibrinogen, and IgG to PEG immobilized silicon surfaces was studied by ellipsometry to evaluate the non-fouling and non-immunogenic properties of the surfaces. The adhesion and proliferation of human fibroblast and Hela cells onto the modified surfaces were investigated to examine their tissue biocompatibility. Coated PEG chains showed the effective depression of both plasma protein adsorption and cell attachment to the modified surfaces. The mechanisms accounting for the reduction of protein adsorption and cell adhesion on modified surfaces were discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：953 / 960

页数：8

共 52 条

[1] STUDIES ON A NEW STRATEGY FOR SURFACE MODIFICATION OF POLYMERIC BIOMATERIALS [J].