Use of differentiated pluripotent stem cells in replacement therapy for treating disease

被引：215

作者：

Fox, Ira J. ^{[1
,2
]}

Daley, George Q. ^{[3
,4
,5
,6
]}

Goldman, Steven A. ^{[7
,8
]}

Huard, Johnny ^{[9
]}

Kamp, Timothy J. ^{[10
]}

Trucco, Massimo ^{[11
]}

机构：

[1] Univ Pittsburgh, Childrens Hosp Pittsburgh, Dept Surg, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA

[3] Boston Childrens Hosp, Boston, MA USA

[4] Dana Farber Canc Inst, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Broad Inst, Dept Biol Chem & Mol Pharmacol, Cambridge, MA 02138 USA

[6] Howard Hughes Med Inst, Chevy Chase, MD USA

[7] Univ Rochester, Med Ctr, Ctr Translat Neuromed, Rochester, NY 14642 USA

[8] Univ Copenhagen, Ctr Basic & Translat Neurosci, DK-1168 Copenhagen, Denmark

[9] Univ Pittsburgh, Sch Med, Dept Orthopaed Surg, Stem Cell Res Ctr, Pittsburgh, PA 15261 USA

[10] Univ Wisconsin, Dept Med, Stem Cell & Regenerat Med Ctr, Cellular & Mol Arrhythmia Res Program,Sch Med & P, Madison, WI USA

[11] Univ Pittsburgh, Childrens Hosp Pittsburgh, Div Immunogenet, Pittsburgh, PA 15213 USA

来源：

SCIENCE | 2014年 / 345卷 / 6199期

关键词：

DUCHENNE MUSCULAR-DYSTROPHY; RED-BLOOD-CELLS; HEPATOCYTE TRANSPLANTATION; PROGENITOR CELLS; SKELETAL-MUSCLE; HUMAN ES; MYOBLAST TRANSPLANTATION; ANIMAL-MODELS; MOUSE MODEL; HEPATOCELLULAR TRANSPLANTATION;

D O I：

10.1126/science.1247391

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pluripotent stem cells (PSCs) directed to various cell fates holds promise as source material for treating numerous disorders. The availability of precisely differentiated PSC-derived cells will dramatically affect blood component and hematopoietic stem cell therapies and should facilitate treatment of diabetes, some forms of liver disease and neurologic disorders, retinal diseases, and possibly heart disease. Although an unlimited supply of specific cell types is needed, other barriers must be overcome. This review of the state of cell therapies highlights important challenges. Successful cell transplantation will require optimizing the best cell type and site for engraftment, overcoming limitations to cell migration and tissue integration, and occasionally needing to control immunologic reactivity, as well as a number of other challenges. Collaboration among scientists, clinicians, and industry is critical for generating new stem cell-based therapies.

引用

页码：889 / +

页数：11

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