Plasma concentrations of VEGF and bFGF in patients with gastric carcinoma

被引：85

作者：

Yoshikawa, T

Tsuburaya, A

Kobayashi, O

Sairenji, M

Motohashi, H

Yanoma, S

Noguchi, Y

机构：

[1] Kanagawa Canc Ctr, Dept Surg 3, Asahi Ku, Yokohama, Kanagawa 2410815, Japan

[2] Kanagawa Canc Ctr, Res Inst, Dept Biochem, Asahi Ku, Yokohama, Kanagawa 2410815, Japan

[3] Yokohama City Univ, Sch Med, Dept Surg 1, Asahi Ku, Yokohama, Kanagawa 2410815, Japan

来源：

CANCER LETTERS | 2000年 / 153卷 / 1-2期

关键词：

vascular endothelial growth factor; basic fibroblast growth factor; gastric cancer; prognostic factor;

D O I：

10.1016/S0304-3835(99)00426-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined plasma levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in 54 patients with gastric carcinoma. Postoperative survival was significantly poorer in patients with plasma VEGF levels more than 10.0 pg/ml at the time of surgery. By an univariate analysis of the factors affecting survival, serosal invasion, lymph node metastasis, peritoneal dissemination, lymphatic vessel invasion, curability, and VEGF proteins were significant. By a multivariate analysis only VEGF levels and curability remained significant. Patients with recurrent disease, including liver metastasis, had significantly higher plasma VEGF concentrations than those with resectable primary tumors. VEGF, not bFGF, may serve as an independent prognosticator and a sensitive indicator for liver recurrence in patients with gastric carcinoma. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：7 / 12

页数：6

共 28 条

[1] INDUCTION OF VASCULAR ENDOTHELIAL TUBULAR MORPHOGENESIS BY HUMAN GLIOMA-CELLS - A MODEL SYSTEM FOR TUMOR ANGIOGENESIS [J].