From Vaccines to Memory and Back

被引：491

作者：

Sallusto, Federica ^{[1
]}

Lanzavecchia, Antonio ^{[1
,2
]}

Araki, Koichi ^{[3
]}

Ahmed, Rafi ^{[3
]}

机构：

[1] Inst Res Biomed, CH-6500 Bellinzona, Switzerland

[2] ETH, Inst Microbiol, CH-8093 Zurich, Switzerland

[3] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

来源：

IMMUNITY | 2010年 / 33卷 / 04期

关键词：

T-CELL MEMORY; HUMAN MONOCLONAL-ANTIBODIES; DENDRITIC CELLS; DENGUE VIRUS; B-CELLS; NEUTRALIZING ANTIBODIES; PROTECTIVE IMMUNITY; HUMORAL IMMUNITY; INTERLEUKIN; 22; EFFECTOR;

D O I：

10.1016/j.immuni.2010.10.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccines work by eliciting an immune response and consequent immunological memory that mediates protection from infection or disease Recently, new methods have been developed to dissect the immune response in experimental animals and humans, which have led to increased understanding of the molecular mechanisms that control differentiation and maintenance of memory T and B cells In this review we will provide an overview of the cellular organization of immune memory and underline some of the outstanding questions on immunological memory and how they pertain to vaccination strategies Finally we will discuss how we can learn about antigen design from the interrogation of our memory T and B cells a journey from vaccines to memory and back

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收藏

页码：451 / 463

页数：13

相关论文

共 130 条

[1] Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells [J].

Acosta-Rodriguez, Eva V. ;

Napolitani, Giorgio ;

Lanzavecchia, Antonio ;

Sallusto, Federica .

NATURE IMMUNOLOGY, 2007, 8 (09) :942-949

[2] Immunological memory and protective immunity: Understanding their relation [J].

Ahmed, R ;

Gray, D .

SCIENCE, 1996, 272 (5258) :54-60

[3] Germinal-center organization and cellular dynamics [J].

Allen, Christopher D. C. ;

Okada, Takaharu ;

Cyster, Jason G. .

IMMUNITY, 2007, 27 (02) :190-202

[4] Duration of humoral immunity to common viral and vaccine antigens [J].

Amanna, Ian J. ;

Carlson, Nichole E. ;

Slifka, Mark K. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (19) :1903-1915

[5] Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells [J].

Auffray, Cedric ;

Sieweke, Michael H. ;

Geissmann, Frederic .

ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :669-692

[6] Restoring function in exhausted CD8 T cells during chronic viral infection [J].

Barber, DL ;

Wherry, EJ ;

Masopust, D ;

Zhu, BG ;

Allison, JP ;

Sharpe, AH ;

Freeman, GJ ;

Ahmed, R .

NATURE, 2006, 439 (7077) :682-687

[7] The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity [J].

Beltramello, Martina ;

Williams, Katherine L. ;

Simmons, Cameron P. ;

Macagno, Annalisa ;

Simonelli, Luca ;

Quyen, Nguyen Than Ha ;

Sukupolvi-Petty, Soila ;

Navarro-Sanchez, Erika ;

Young, Paul R. ;

de Silva, Aravinda M. ;

Rey, Felix A. ;

Varani, Luca ;

Whitehead, Stephen S. ;

Diamond, Michael S. ;

Harris, Eva ;

Lanzavecchia, Antonio ;

Sallusto, Federica .

CELL HOST & MICROBE, 2010, 8 (03) :271-283

[8] An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis [J].

Berry, Matthew P. R. ;

Graham, Christine M. ;

McNab, Finlay W. ;

Xu, Zhaohui ;

Bloch, Susannah A. A. ;

Oni, Tolu ;

Wilkinson, Katalin A. ;

Banchereau, Romain ;

Skinner, Jason ;

Wilkinson, Robert J. ;

Quinn, Charles ;

Blankenship, Derek ;

Dhawan, Ranju ;

Cush, John J. ;

Mejias, Asuncion ;

Ramilo, Octavio ;

Kon, Onn M. ;

Pascual, Virginia ;

Banchereau, Jacques ;

Chaussabel, Damien ;

O'Garra, Anne .

NATURE, 2010, 466 (7309) :973-U98

[9] In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination [J].

Bonifaz, LC ;

Bonnyay, DP ;

Charalambous, A ;

Darguste, DI ;

Fujii, SI ;

Soares, H ;

Brimnes, MK ;

Moltedo, B ;

Moran, TM ;

Steinman, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (06) :815-824

[10] THE CONFIRMATION AND MAINTENANCE OF SMALLPOX ERADICATION [J].

BREMAN, JG ;

ARITA, I .

NEW ENGLAND JOURNAL OF MEDICINE, 1980, 303 (22) :1263-1273

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