Umbilical cord blood transplantation: current practice and future innovations

被引：63

作者：

Barker, JN

Wagner, JE

机构：

[1] Univ Minnesota, Sch Med, Dept Med, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Dept Pediat, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2003年 / 48卷 / 01期

关键词：

hematopoietic stem cells; umbilical cord blood; allogeneic transplantation; acute leukemia;

D O I：

10.1016/S1040-8428(03)00092-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As a source of hematopoietic stem cells (HSCs), umbilical cord blood (UCB) has the advantages of speed of availability, tolerance of 1-2 antigen HLA mismatch, and a low incidence of severe GVHD. Thus, UCB represents a highly convenient HSC source that may significantly extend the HSC donor pool. UCB transplantation (UCBT) has become a standard practice in the treatment of pediatric malignancies. Now, UCBT is being investigated in adults using both conventional and non-myeloablative preparative regimens. As graft cell dose is the major factor determining hematopoietic recovery and survival in URD UCBT, methods to increase cell dose such as multiple-unit transplant and ex vivo expansion are being pursued. This review outlines the current status of UCBT with emphasis on current and future innovations. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

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页码：35 / 43

页数：9

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