Identification of optimal combinations for empirical dual antimicrobial therapy of pseudomonas aeruginosa infection: Potential role of a combination antibiogram

被引：165

作者：

Mizuta, Mari

Linkin, Darren R.

Nachamkin, Irving

Fishman, Neil O.

Weiner, Mark G.

Sheridan, Angela

Lautenbach, Ebbing

机构：

[1] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Div Infect Dis, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Div Gen Internal Med, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Dept Med, Philadelphia, PA 19104 USA

[5] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[6] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Dept Pathol, Philadelphia, PA 19104 USA

[7] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Lab Med, Philadelphia, PA 19104 USA

[8] Univ Penn, Sch Med, Ctr Educ & REs Therapeut, Philadelphia, PA 19104 USA

来源：

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY | 2006年 / 27卷 / 04期

关键词：

D O I：

10.1086/503175

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

To better determine the optimal combinations for empirical dual antimicrobial therapy of Pseudomonas aeruginosa infection, we evaluated the utility of a novel combination antibiogram. Although the combination antibiogram allowed modest fine-tuning of choices for dual antibiotic therapy, selections based on the 2 antibiograms did not differ substantively. Drug combinations with the broadest coverage were consistently composed of an aminoglycoside and a beta-lactam.

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页码：413 / 415

页数：3

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