Olfactory centres in Alzheimer's disease:: olfactory bulb is involved in early Braak's stages

被引：186

作者：

Kovács, T

Cairns, NJ

Lantos, PL

机构：

[1] Inst Psychiat, Dept Neuropathol, London SE5 8AF, England

[2] Semmelweis Univ, Dept Neurol, Budapest, Hungary

来源：

NEUROREPORT | 2001年 / 12卷 / 02期

关键词：

Alzheimer's disease; Braak's staging; olfactory bulb; olfactory cortex;

D O I：

10.1097/00001756-200102120-00021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In Alzheimer's disease (AD), neurofibrillary tangles spread from the entorhinal cortex to the limbic system, then to neocortical areas, according to the Braak's stages. Olfaction is impaired in early stages of AD. The aim of this study was to describe the pathology of the cortical olfactory centres in relation to Braak's stages determining the earliest site of pathology. We examined 15 control and 15 AD cases. The primary olfactory cortices were involved in more advanced Braak's stages, while olfactory bulbs were damaged in very early (i.e. Braak's stage 0 or 1) stages. These results are supporting the fact that olfaction might be an early marker in AD and argues against the hypothesis that AD pathology is spreading through the olfactory system. NeuroReport 12:285-288 (C) 2001 Lippincott Williams & Wilkins.

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页码：285 / 288

页数：4

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