Cytochrome P450 monooxygenases

被引：73

作者：

Wong, LL ^{[1
]}

机构：

[1] Dept Chem, Inorgan Chem Lab, Oxford OX1 3QR, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1998年 / 2卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(98)80068-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The field of P450 research is progressing rapidly. The active sites of structurally characterized bacterial P450 enzymes have been rationally re-engineered to alter both substrate specificity and selectivity of substrate oxidation. Many human P450 enzymes have been functionally expressed and new methods of substrate turnover described. These developments, arising from our increased understanding of the chemistry and molecular biology of P450 enzymes, open up new and exciting research directions.

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页码：263 / 268

页数：6

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