Clinical evaluation of systemic doxycycline and ibuprofen administration as an adjunctive treatment for adult periodontitis

被引:39
作者
Ng, VWK
Bissada, NF
机构
[1] Case Western Reserve Univ, Sch Dent, Dept Periodont, Cleveland, OH 44106 USA
[2] Univ Detroit Mercy, Sch Dent, Dept Periodont, Detroit, MI 48221 USA
关键词
comparison study; doxycycline therapeutic use; ibuprofen therapeutic use; planing; scaling; periodontitis drug use;
D O I
10.1902/jop.1998.69.7.772
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The objective of this study was to compare the efficacy of a systemic antibiotic (doxycycline) and a non-steroidal anti-inflammatory drug (ibuprofen), administered either separately or combined, as an adjunctive treatment of scaling/root planing (SRP). Thirty-two subjects diagnosed with generalized moderate adult periodontitis and having at least 2 teeth with greater than or equal to 5 mm probing depth were randomly divided into 4 groups. Each group was treated with oral doxycycline and/or ibuprofen for 6 weeks as follows: group 1, doxycycline 200 mg the first day followed by 100 mg per day; group 2, ibuprofen 800 mg per day; group 3, doxycycline plus ibuprofen scheduled as in groups 1 and 2; group 4, one placebo capsule/day (control). A split mouth design was utilized in each subject such that half of the teeth received one session of scaling/root planing (SRP), while the other half received no SRP. Plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment level (CAL) using a customized acrylic stent were recorded at baseline and at 3, 6, 12, and 24 weeks following SRP. Analysis using ANOVA and Student t-test showed statistical significance (P less than or equal to 0.05) from baseline data in: 1) gains of 0.4 mm and 0.5 mm of CAL for groups 1 and 3, respectively; 2) reduction of 0.7 mm PD for group 3; 3) reduction of 0.4 and 0.1 GI scores for groups 1 and 3, respectively; and 4) gain of 0.5 mm CAL and reductions of 0.4 mm PD and 0.2 GI score for the SRP group when compared to the no SRP group at 24 weeks. It may be concluded that the adjunctive use of systemic doxycycline alone or in combination with ibuprofen results in a statistically significant, yet modest clinical, improvement beyond that obtained by scaling/root planing.
引用
收藏
页码:772 / 776
页数:5
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