BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation

被引：67

作者：

Logarajah, S

Hunter, P

Kraman, M

Steele, D

Lakhani, S

Bobrow, L

Venkitaraman, A

Wagner, S

机构：

[1] Univ Cambridge, Dept Med, Wellcome Trust Immunol Unit, Cambridge CB2 2SP, England

[2] Inst Canc Res, Chester Beatty Labs, Breakthrough Toby Robbins Breast Canc Res Ctr, London SW3 6JB, England

[3] Univ Cambridge, Dept Pathol, Cambridge CB2 2XZ, England

[4] Univ Cambridge, Dept Oncol, Cambridge CB2 2XZ, England

[5] Univ Cambridge, MRC, Canc Cell Unit, Cambridge CB2 2XZ, England

[6] Univ Cambridge, Dept Haematol, Cambridge CB2 2XZ, England

来源：

ONCOGENE | 2003年 / 22卷 / 36期

基金：

英国惠康基金;

关键词：

mammary epithelium; differentiation; breast cancer; BCL-6; STAT;

D O I：

10.1038/sj.onc.1206689

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Appropriately timed proliferation, differentiation and apoptosis are essential to the normal functions of the mammary epithelium. Here, we report that the transcription factor BCL-6 is expressed in mammary epithelium in nonpregnant animals as well as during early pregnancy. When overexpressed in the nontransformed EpH4 mammary epithelial cell line, BCL-6 prevents the STAT-driven expression of the milk protein beta-casein and duct formation, and prevents apoptosis. Consistent with an antiapoptotic function, we demonstrate that BCL-6 is expressed in 68% of histologically high-grade ductal breast carcinomas, which are clinically the most aggressive. BCL-6 has previously been characterized as a regulator of B lymphocyte growth and development, but our work identifies a novel role for it in mammary epithelial differentiation, which may also implicate it in carcinogenesis.

引用

页码：5572 / 5578

页数：7

共 27 条

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