Effects of zinc deficiency and supplementation on plasma leptin levels in rats

被引：28

作者：

Baltaci, AK ^{[1
]}

Mogulkoc, R

Halifeoglu, I

机构：

[1] Selcuk Univ, Meram Med Sch, Dept Physiol, Konya, Turkey

[2] Firat Univ, Sch Med, Dept Biochem, Elazig, Turkey

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 2005年 / 104卷 / 01期

关键词：

zinc deficiency and supplementation; leptin; rat;

D O I：

10.1385/BTER:104:1:041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The effects of zinc deficiency and supplementation on plasma leptin levels were studied in Sprague-Dawley rats. After 6 wk on a zinc-deficient diet containing 0.65 ppm Zn/g, the mean body weight was significantly lower than that of normal or zinc-supplemented rats, which showed no difference among them. The plasma leptin and zinc levels were lowest in zinc-deficient animals and highest in those that received a normal diet and daily intraperitioneal injections of 3 mg Zn/kg. These results indicate that zinc deficiency leads to a significant inhibition in plasma leptin levels, whereas zinc supplementation significantly increases plasma leptin.

引用

页码：41 / 46

页数：6

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