Rational design and synthesis of unsaturated 2,5-dioxopiperazine derivatives as potential protein tyrosine kinase inhibitors

被引：31

作者：

Li, WR ^{[1
]}

Peng, SZ ^{[1
]}

机构：

[1] Natl Cent Univ, Dept Chem, Chungli 32054, Taiwan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(98)01599-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first general method for the synthesis of a library of trifunctionalized (Z)-3-alkylidene-2,5-piperazinediones as potential protein tyrosine kinase inhibitors from commercially available amino compounds, alpha-keto acids and aldehydes using a novel cyclization/cleavage strategy on solid support is described. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：7373 / 7376

页数：4

相关论文

共 15 条

[1]

[Anonymous], ANGEW CHEM INT EDIT, DOI DOI 10.1002/ANIE.199622881

[2] AN EXPEDIENT AND HIGH-YIELDING METHOD FOR THE SOLID-PHASE SYNTHESIS OF DIVERSE 1,4-BENZODIAZEPINE-2,5-DIONES [J].

BOOJAMRA, CG ;

BUROW, KM ;

ELLMAN, JA .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (18) :5742-5743

[3] RACEMIZATION STUDIES DURING SOLID-PHASE PEPTIDE-SYNTHESIS USING AZABENZOTRIAZOLE-BASED COUPLING REAGENTS [J].

CARPINO, LA ;

EL-FAHAM, A ;

ALBERICIO, F .

TETRAHEDRON LETTERS, 1994, 35 (15) :2279-2282

[4] N-METHYLAMINO ACIDS IN PEPTIDE-SYNTHESIS .5. SYNTHESIS OF N-TERT-BUTYLOXYCARBONYL, N-METHYLAMINO ACIDS BY N-METHYLATION [J].

CHEUNG, ST ;

BENOITON, NL .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1977, 55 (05) :906-910

[5] SOLID-PHASE SYNTHESIS OF LAVENDUSTIN-A AND ANALOGS [J].

GREEN, J .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (13) :4287-4290

[6]

KALJUSTE K, 1993, INT J PEPT PROT RES, V42, P118

[7] Solid phase synthesis of a diketopiperazine catalyst containing the unnatural amino acid (S)-norarginine [J].

Kowalski, J ;

Lipton, MA .

TETRAHEDRON LETTERS, 1996, 37 (33) :5839-5840

[8] The ''one-bead-one-compound'' combinatorial library method [J].

Lam, KS ;

Lebl, M ;

Krchnak, V .

CHEMICAL REVIEWS, 1997, 97 (02) :411-448

[9] TYRPHOSTINS - TYROSINE KINASE BLOCKERS AS NOVEL ANTIPROLIFERATIVE AGENTS AND DISSECTORS OF SIGNAL TRANSDUCTION [J].

LEVITZKI, A .

FASEB JOURNAL, 1992, 6 (14) :3275-3282

[10] Synthesis of a reduced ring analog of didemnin B [J].

Ramanjulu, JM ;

Ding, XB ;

Joullie, MM ;

Li, WR .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (15) :4961-4969