Fibrinolytic and anticoagulative activities from the earthworm Eisenia foetida

被引：59

作者：

Hrzenjak, T

Popovic, M

Bozic, T

Grdisa, M

Kobrehel, D

Tiska-Rudman, L

机构：

[1] Univ Zagreb, Fac Med Vet, Dept Biol, Zagreb 1000, Croatia

[2] Rudjer Boskovic Inst, Dept Mol Med, Zagreb 10000, Croatia

[3] PLIVA Inst, Zagreb 10000, Croatia

[4] Univ Zagreb, Clin Tumors, Zagreb 10000, Croatia

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1998年 / 119卷 / 04期

关键词：

Eisenia foetida; Lumbricidae; serine peptidases; fibrinolytic activity; anticoagulative activity;

D O I：

10.1016/S0305-0491(98)00060-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biologically active glycolipoprotein complex (G-90) isolated from whole earthworm tissue extract shows anticoagulative and fibrinolytic activities. We isolated two tyrosine like serine peptidases with molecular masses of 34 kDa (P I) and 23 kDa (P II), respectively. P I peptidase is autocatalytically degraded to P II. Both peptidases exhibit fibrinolytic and anticoagulative activities. The activity of P I is much higher. P I in concentration of 10(5) ng ml(-1) of plasma shortened the physiological time of fibrin clot lysis by 54% and completely inhibited blood clotting at a concentration of 10(3) ng ml(-1) of venous blood. (C) 1998 Published by Elsevier Science Inc. All rights reserved.

引用

页码：825 / 832

页数：8

共 38 条

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