RRR-γ-tocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling

被引：24

作者：

Yu, Weiping ^{[2
]}

Park, Sook-Kyung ^{[2
]}

Jia, Li ^{[2
]}

Tiwary, Richa ^{[2
]}

Scott, Wenjun W. ^{[2
]}

Li, Jing ^{[2
]}

Wang, Pei ^{[2
]}

Simmons-Menchaca, Marla ^{[2
]}

Sanders, Bob G. ^{[2
]}

Kline, Kimberly ^{[1
]}

机构：

[1] Univ Texas Austin, Div Nutr A2703, Austin, TX 78712 USA

[2] Univ Texas Austin, Sch Biol Sci, Austin, TX 78712 USA

来源：

CANCER LETTERS | 2008年 / 259卷 / 02期

关键词：

human breast cancer cells; RRR-gamma-tocopherol; DR5; apoptosis; TRAIL; vitamin E;

D O I：

10.1016/j.canlet.2007.10.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Goal of this study was to investigate the pro-apoptotic properties of RRR-gamma-tocopherol (gamma T) in human breast cancer cells. gamma T was shown to induce cancer cells but not normal cells to undergo apoptosis, sensitize cancer cells to Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL)-induced apoptosis, and increase death receptor 5 (DR5) mRNA, protein and cell surface expression. Knockdown of DR5 attenuated gamma T-induced apoptosis. Investigations of post-receptor signaling showed: caspase-8, Bid and Bax activation, increases in mitochondria permeability, cytochrome c release and caspase-9 activation. Thus, gamma T is a potent pro-apoptotic agent for human breast cancer cells inducing apoptosis via activation of DR5-mediated apoptotic pathway. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：165 / 176

页数：12

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