Nanopore arrays for stable and functional free-standing lipid bilayers

被引：102

作者：

Han, Xiaojun ^{[1
]}

Studer, Andre ^{[1
]}

Sehr, Harald ^{[3
]}

Geissbuehler, Isabelle ^{[1
]}

Di Berardino, Marco ^{[2
]}

Winkler, Fritz K. ^{[1
]}

Tiefenauer, Louis X. ^{[1
]}

机构：

[1] Paul Scherrer Inst, Biomol Res, CH-5232 Villigen, Switzerland

[2] Leister Proc Technol Axetris, CH-6056 Kagiswil, Switzerland

[3] Paul Scherrer Inst, Lab Micro & Nano Techol, CH-5232 Villigen, Switzerland

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 24期

关键词：

D O I：

10.1002/adma.200700468

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lipid bilayers; in nanopores are stable for days. The stability depends on the nature of the lipid as well on the pore diameter as investigated by impedance spectroscopy. Bilayers formed of palmitoyl-oleoyl-phosphatidylcholine are stable up to 4 days in 200 nm pores regularly arrayed in a 300 nm thin silicon nitride support. The transport of K+ across bilayers by valinomycin demonstrates that this support material has a high potential to monitor functions of membrane proteins.

引用

页码：4466 / +

页数：6

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