Mismatch responses related to temporal discrimination of somatosensory stimulation

被引:51
作者
Akatsuka, K [1 ]
Wasaka, T
Nakata, H
Inui, K
Hoshiyama, M
Kakigi, R
机构
[1] Natl Inst Physiol Sci, Dept Integrat Physiol, Okazaki, Aichi 4448585, Japan
[2] Grad Univ Adv Studies, Dept Physiol Sci, Sch Life Sci, Kanagawa, Japan
[3] Japan Space Forum, Tokyo, Japan
[4] Nagoya Univ, Dept Hlth Sci, Fac Med, Nagoya, Aichi, Japan
[5] Japan Sci & Technol Agcy, RISTEX, Tokyo, Japan
关键词
mismatch negativity; temporal discrimination; ERP; two point discrimination;
D O I
10.1016/j.clinph.2005.04.021
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To determine the existence of a preattentively evoked somatosensory mismatch negativity component and to investigate the use of that component in objective clinical diagnostics. Methods: First we determined the temporal discrimination threshold (DT) of paired stimuli in each subject, and applied two sequential electrical stimuli to the hand with paired stimulus times of (1) DT -10 ms, (2) DT -30 ms and (3) DT +50 ms. Then, we recorded ERPs using an oddball paradigm, frequent (standard) and rare (deviant). We used two stimuli, DT-30 ms and DT-10 ms, in the first experiment, and DT -30 ms and DT +50 ms, in the second experiment. Results: In each experiment, two specific components, a negative component peaking at approximately 60 ms (N60) and a large positive component peaking around 100-200 ms (P150), were identified, mainly following the deviant stimulus, which were considered somatosensory mismatch components. N60 was more remarkably identified in the second experiment and P150 in the first. Conclusions: N60 might be generated during tasks which subjects can clearly discriminate, but P150, which seems to correspond to auditory mismatch negativity, might be generated in tasks which require fine discrimination. Significance: We confirmed that our new method could be used for the objective examination of temporal discrimination. (c) 2005 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:1930 / 1937
页数:8
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