Death by a thousand cuts: Granzyme pathways of programmed cell death

被引：478

作者：

Chowdhury, Dipanjan ^{[1
,2
]}

Lieberman, Judy ^{[3
,4
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Radiat Oncol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Immune Dis Inst, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2008年 / 26卷

关键词：

cytotoxic T lymphocyte; cytotoxic granule; natural killer cell; serine protease; granule exocytosis; serpin;

D O I：

10.1146/annurev.immunol.26.021607.090404

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The granzymes ire cell death-inducing enzymes, stored in the cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, that are released during granule exocytosis when a specific virus-infected or transformed target cell is marked for elimination. Recent work suggests that this homologous family of serine esterases can activate at least three distinct pathways of cell death. This redundancy likely evolved to provide protection against pathogens and tumors with diverse strategies for evading cell death. This review discusses what is known about granzyme-mediated pathways of cell death as well as recent studies that implicate granzymes in immune regulation and extracellular proteolytic functions in inflammation.

引用

页码：389 / 420

页数：32

共 208 条

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