Effective dose range of candesartan cilexetil for systemic hypertension

被引：19

作者：

Bell, TP

DeQuattro, V

Lasseter, KC

Ruff, D

Hardison, JD

Cushing, D

Kezer, AE

Michelson, EL

机构：

[1] Univ S Alabama, Med Ctr, Mobile, AL USA

[2] Univ So Calif, Sch Med, Los Angeles, CA USA

[3] Clin Pharmacol Associates, Miami, FL USA

[4] Healthcare Discoveries, San Antonio, TX USA

[5] Astra Pharmaceut LP, Wayne, PA USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1999年 / 83卷 / 02期

关键词：

D O I：

10.1016/S0002-9149(98)00837-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The results of this randomized, double-blind, placebo-controlled, forced-dose titration study in a diverse population of hypertensive patients in the US indicate that candesartan cilexetil has clinically meaningful dose-related blood pressure-lowering effects and that maximum blood pressure reduction is achieved with doses of 16 and 32 mg given once daily. This study confirms that candesartan cilexetil is a highly effective antihypertensive agent with an excellent tolerability and safety profile, without dose-related adverse effects.

引用

页码：272 / +

页数：5

共 6 条

[1]

Belcher G, 1997, J HUM HYPERTENS, V11, pS85

[2]

Elmfeldt D, 1997, J HUM HYPERTENS, V11, pS49

[3] Drug therapy - Angiotensin receptors and their antagonists [J].

Goodfriend, TL ;

Elliott, ME ;

Catt, KJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (25) :1649-1654

[4]

Heuer HJ, 1997, J HUM HYPERTENS, V11, pS55

[5] Angiotensin II receptor inhibition - A new therapeutic principle [J].

Messerli, FH ;

Weber, MA ;

Brunner, HR .

ARCHIVES OF INTERNAL MEDICINE, 1996, 156 (17) :1957-1965

[6]

SHIBOUTA Y, 1993, J PHARMACOL EXP THER, V266, P114

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