Oxidation of retinyl acetate and analogues by nitric oxide and nitrogen dioxide

被引：8

作者：

Afzal, M ^{[1
]}

Walton, JC ^{[1
]}

机构：

[1] UNIV ST ANDREWS,SCH CHEM,ST ANDREWS KY16 9ST,FIFE,SCOTLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 19期

关键词：

D O I：

10.1016/0960-894X(96)00422-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nitric oxide did not react directly with retinyl acetate but, in the presence of an initiator, a series of nitroxide radicals was produced and observed by EPR spectroscopy. Product analyses showed that rapid oxidative degradation of retinyl acetate gave a series of carbonyl compounds. NO operating in concert with a self-derived initiator such as NO2 on unsaturated lipids could account for the cytotoxicity of this molecule. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2329 / 2332

页数：4

共 17 条

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