Of mice and man: TLR11 (finally) finds profilin

被引：92

作者：

Lauw, FN

Caffrey, DR

Golenbock, DT ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA

[2] Pfizer Discovery Technol Ctr, Cambridge, MA 02139 USA

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 10期

关键词：

D O I：

10.1016/j.it.2005.08.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) are primordial pathogen-recognition proteins that function as sentinels for the innate immune system. One of the TLR mysteries relates to TLR11, a receptor present in mice, but not humans, and known to recognize uropathogenic Escherichia coli. The first defined ligand for TLR11 has now been described as a profilin-like protein from Toxoplasma gondii. This discovery potentially gives us important clues as to how a gene expressed in mice, but not humans, actually relates to human infectious diseases.

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页码：509 / 511

页数：3

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