Conjugated linoleic acid increased C-reactive protein in human subjects

被引：60

作者：

Smedman, A ^{[1
]}

Basu, S

Jovinge, S

Fredrikson, GN

Vessby, B

机构：

[1] Uppsala Univ, Dept Publ Hlth & Caring Sci, Clin Nutr Res Unit, Uppsala, Sweden

[2] Lund Univ, Univ Hosp MAS, Dept Med Cardiol, Malmo, Sweden

来源：

BRITISH JOURNAL OF NUTRITION | 2005年 / 94卷 / 05期

关键词：

conjugated linoleic acid; C-reactive protein; tumour necrosis factor-alpha; inflammation;

D O I：

10.1079/BJN20041419

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F-2 alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.

引用

页码：791 / 795

页数：5

共 37 条

[1] Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men
Albers, R
van der Wielen, RPJ
Brink, EJ
Hendriks, HFJ
Dorovska-Taran, VN
Mohede, ICM
[J]. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2003, 57 (04) : 595 - 603
[2] Basu S, 2000, CLIN SCI, V99, P511, DOI [10.1042/CS20000116, 10.1042/cs0990511]
[3] Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients
Basu, S
[J]. TOXICOLOGY, 2003, 189 (1-2) : 113 - 127
[4] Radioimmunoassay of 15-keto-13,14-dihydro-prostaglandin F2α:: an index for inflammation via cyclooxygenase catalysed lipid peroxidation
Basu, S
[J]. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1998, 58 (05): : 347 - 352
[5] Conjugated linoleic acid induces lipid peroxidation in humans
Basu, S
Smedman, A
Vessby, B
[J]. FEBS LETTERS, 2000, 468 (01) : 33 - 36
[6] Conjugated linoleic acid reduces body fat mass in overweight and obese humans
Blankson, H
Stakkestad, JA
Fagertun, H
Thom, E
Wadstein, J
Gudmundsen, O
[J]. JOURNAL OF NUTRITION, 2000, 130 (12) : 2943 - 2948
[7] Linoleic acid-stimulated vascular adhesion molecule-1 expression in endothelial cells depends on nuclear factor-κB activation
Dichtl, W
Ares, MPS
Jönson, AN
Jovinge, S
Pachinger, O
Giachelli, CM
Hamsten, A
Eriksson, P
Nilsson, J
[J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2002, 51 (03): : 327 - 333
[8] Relation of C-reactive protein to body fat distribution and features of the metabolic syndrome in Europeans and South Asians
Forouhi, NG
Sattar, N
McKeigue, PM
[J]. INTERNATIONAL JOURNAL OF OBESITY, 2001, 25 (09) : 1327 - 1331
[9] Inflammatory status and insulin resistance
Grimble, RF
[J]. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2002, 5 (05) : 551 - 559
[10] Inflammation, metabolic syndrome, and diet responsiveness
Grundy, SM
[J]. CIRCULATION, 2003, 108 (02) : 126 - 128

← 1 2 3 4 →