Conjugated linoleic acid increased C-reactive protein in human subjects

被引:60
作者
Smedman, A [1 ]
Basu, S
Jovinge, S
Fredrikson, GN
Vessby, B
机构
[1] Uppsala Univ, Dept Publ Hlth & Caring Sci, Clin Nutr Res Unit, Uppsala, Sweden
[2] Lund Univ, Univ Hosp MAS, Dept Med Cardiol, Malmo, Sweden
关键词
conjugated linoleic acid; C-reactive protein; tumour necrosis factor-alpha; inflammation;
D O I
10.1079/BJN20041419
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F-2 alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.
引用
收藏
页码:791 / 795
页数:5
相关论文
共 37 条
  • [1] Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men
    Albers, R
    van der Wielen, RPJ
    Brink, EJ
    Hendriks, HFJ
    Dorovska-Taran, VN
    Mohede, ICM
    [J]. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2003, 57 (04) : 595 - 603
  • [2] Basu S, 2000, CLIN SCI, V99, P511, DOI [10.1042/CS20000116, 10.1042/cs0990511]
  • [3] Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients
    Basu, S
    [J]. TOXICOLOGY, 2003, 189 (1-2) : 113 - 127
  • [4] Radioimmunoassay of 15-keto-13,14-dihydro-prostaglandin F2α:: an index for inflammation via cyclooxygenase catalysed lipid peroxidation
    Basu, S
    [J]. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1998, 58 (05): : 347 - 352
  • [5] Conjugated linoleic acid induces lipid peroxidation in humans
    Basu, S
    Smedman, A
    Vessby, B
    [J]. FEBS LETTERS, 2000, 468 (01) : 33 - 36
  • [6] Conjugated linoleic acid reduces body fat mass in overweight and obese humans
    Blankson, H
    Stakkestad, JA
    Fagertun, H
    Thom, E
    Wadstein, J
    Gudmundsen, O
    [J]. JOURNAL OF NUTRITION, 2000, 130 (12) : 2943 - 2948
  • [7] Linoleic acid-stimulated vascular adhesion molecule-1 expression in endothelial cells depends on nuclear factor-κB activation
    Dichtl, W
    Ares, MPS
    Jönson, AN
    Jovinge, S
    Pachinger, O
    Giachelli, CM
    Hamsten, A
    Eriksson, P
    Nilsson, J
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2002, 51 (03): : 327 - 333
  • [8] Relation of C-reactive protein to body fat distribution and features of the metabolic syndrome in Europeans and South Asians
    Forouhi, NG
    Sattar, N
    McKeigue, PM
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2001, 25 (09) : 1327 - 1331
  • [9] Inflammatory status and insulin resistance
    Grimble, RF
    [J]. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2002, 5 (05) : 551 - 559
  • [10] Inflammation, metabolic syndrome, and diet responsiveness
    Grundy, SM
    [J]. CIRCULATION, 2003, 108 (02) : 126 - 128