Suggestive evidence for inhibitory effects of galanin on mesolimbic dopaminergic neurotransmission

被引:47
作者
Ericson, E
Ahlenius, S [1 ]
机构
[1] Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden
[2] Astra Arcus, Dept Pharmacol, SE-15185 Sodertalje, Sweden
关键词
galanin(rat); galantide; monoamine; dopamine; synthesis; behavior; rat;
D O I
10.1016/S0006-8993(99)01144-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The objective was to examine effects of galanin(rat) on forebrain monoamine synthesis and on spontaneous locomotor activity in the rat. The rate of monoamine synthesis was estimated by measuring the accumulation of L-DOPA and 5-HTP, following inhibition of cerebral aromatic L-amino acid decarboxylase by means of NSD-1015 (100 mg kg(-1) i.p.), after i.c.v. or intracerebral administration of galanin in adult male Wistar rats. Spontaneous locomotor activity was observed in an automated open-field arena (approximate to 0.5 m(2)). The i.c.v. administration of galanin (0.5-5.0 nmol bilaterally) produced a dose-dependent, statistically significant, increase in DOPA accumulation throughout the neostriatum, and in the olfactory bulb, indicating an increase in the rate of DA synthesis. No increase was observed in brain areas where noradrenaline is the predominant catecholamine, such as the neocortex or the ventral hippocampus. In addition, there was a tendency for an increase in 5-HTP accumulation in the dorso-lateral neostriatum and in the accumbens. The same i.c.v. administration of galanin produced a dose-dependent, and statistically significant, decrease in spontaneous locomotor activity. The effect on forebrain DA synthesis could also be produced by local bilateral application of galanin (2 X 1 nmol) into the ventral tegmental area, but not the nucleus accumbens (2 X 2 nmol). There were no effects on forebrain DOPA or 5-HTP accumulation by the local application of galanin into the locus coeruleus, or into the dorsal raphe nucleus. It is concluded that the neuropeptide galanin modulates forebrain dopaminergic neurotransmission. The effect appears to be mediated at the somato-dendritic level of the meso-neostriatal pathway, and could perhaps be utilized to normalize perturbations ascribed to dysfunction in this neuronal pathway, such as schizophrenia. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:200 / 209
页数:10
相关论文
共 71 条
  • [1] AGUILA MC, 1992, NEUROENDOCRINOLOGY, V56, P889
  • [2] DIFFERENT ALPHA-ADRENORECEPTORS IN CENTRAL NERVOUS-SYSTEM MEDIATING BIOCHEMICAL AND FUNCTIONAL EFFECTS OF CLONIDINE AND RECEPTOR BLOCKING-AGENTS
    ANDEN, NE
    GRABOWSKA, M
    STROMBOM, U
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1976, 292 (01) : 43 - 52
  • [3] ANDEN NE, 1980, HDB EXPT PHARM, V54, P429
  • [4] CHARACTERIZATION OF TROUT GALANIN AND ITS DISTRIBUTION IN TROUT BRAIN AND PITUITARY
    ANGLADE, I
    WANG, YX
    JENSEN, J
    TRAMU, G
    KAH, O
    CONLON, JM
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 350 (01) : 63 - 74
  • [5] Azumaya Y, 1996, BRAIN RES, V727, P187
  • [6] M-15 - HIGH-AFFINITY CHIMERIC PEPTIDE THAT BLOCKS THE NEURONAL ACTIONS OF GALANIN IN THE HIPPOCAMPUS, LOCUS-CERULEUS, AND SPINAL-CORD
    BARTFAI, T
    BEDECS, K
    LAND, T
    LANGEL, U
    BERTORELLI, R
    GIROTTI, P
    CONSOLO, S
    XU, XJ
    WIESENFELDHALLIN, Z
    NILSSON, S
    PIERIBONE, VA
    HOKFELT, T
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (23) : 10961 - 10965
  • [7] BARTFAI T, 1993, CRIT REV NEUROBIOL, V7, P229
  • [8] Bartfai Tamas, 1995, P563
  • [9] ANATOMICAL DISTRIBUTION OF GALANIN-LIKE IMMUNOREACTIVITY IN THE BRAIN AND PITUITARY OF TELEOST FISHES
    BATTEN, TFC
    MOONS, L
    CAMBRE, M
    VANDESANDE, F
    [J]. NEUROSCIENCE LETTERS, 1990, 111 (1-2) : 12 - 17
  • [10] GALANIN - 10 YEARS WITH A NEUROENDOCRINE PEPTIDE
    BEDECS, K
    BERTHOLD, M
    BARTFAI, T
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1995, 27 (04) : 337 - 349