The calcium-independent receptor of alpha-latrotoxin is not a neurexin

被引：82

作者：

Krasnoperov, VG

Beavis, R

Chepurny, OG

Little, AR

Plotnikov, AN

Petrenko, AG

机构：

[1] NYU, MED CTR, DEPT ENVIRONM MED, NEW YORK, NY 10016 USA

[2] NYU, MED CTR, DEPT PHYSIOL & NEUROSCI, NEW YORK, NY 10016 USA

[3] NYU, MED CTR, SKIRBALL INST BIOMED RES, NEW YORK, NY 10016 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 227卷 / 03期

关键词：

D O I：

10.1006/bbrc.1996.1598

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

alpha-Latrotoxin (alpha-LTx), a vertebrate neurotoxin isolated from Black Widow Spider venom, causes massive spontaneous neurotransmitter release. The molecular mechanism(s) by which the toxin exerts its effect is largely unknown. Here we report identification and purification of a novel membrane receptor with high affinity for alpha-LTx. Unlike neurexin Ia, a previously described high affinity alpha-LTx receptor, this novel protein binds alpha-LTx independently of Ca2+ presence and therefore may be a mediator of the calcium-independent stimulation of neurotransmitter release by alpha-latrotoxin. The major protein component of calcium-independent alpha-LTx receptors is a novel Mr 120,000 protein which does not belong to the neurexin family. Among several tissues tested, the Mr 120,000 protein was found only in brain. (C) 1996 Academic Press, Inc.

引用

页码：868 / 875

页数：8

共 30 条

[1]

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