Endogenous synthesis of coenzyme Q in eukaryotes

被引：217

作者：

Tran, UyenPhuong C. ^{[1
]}

Clarke, Catherine F. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Inst Mol Biol, Los Angeles, CA 90095 USA

来源：

MITOCHONDRION | 2007年 / 7卷

关键词：

coenzyme Q; mitochondria; eukaryotes; CoQ mutant; mitochondrial protein import; multi-subunit CoQ polypeptide biosynthetic complex; Saccharomyces cerevisiae; yeast;

D O I：

10.1016/j.mito.2007.03.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Coenzyme Q (Q functions in the mitochondrial respiratory chain and serves as a lipophilic antioxidant. There is increasing interest in the use of Q as a nutritional supplement. Although, the physiological significance of Q is extensively investigated in eukaryotes, ranging from yeast to human, the eukaryotic Q biosynthesis pathway is best characterized in the budding yeast Saccharomyces cerevisiae. At least ten genes (COQ1-COQ10) have been shown to be required for Q biosynthesis and function in respiration. This review highlights recent knowledge about the endogenous synthesis of Q in eukaryotes, with emphasis on S. cerevisiae as a model system. (c) 2007 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：S62 / S71

页数：10

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