Irp9, encoded by the high-pathogenicity island of Yersinia enterocolitica, is able to convert chorismate into salicylate, the precursor of the siderophore yersiniabactin

被引：48

作者：

Pelludat, C

Brem, D

Heesemann, E

机构：

[1] Max Von Pettenkofer Inst Hyg & Med Microbiol, D-80336 Munich, Germany

[2] ETHZ, D BIOL, Inst Mikrobiol, CH-8092 Zurich, Switzerland

来源：

JOURNAL OF BACTERIOLOGY | 2003年 / 185卷 / 18期

关键词：

D O I：

10.1128/JB.185.18.5648-5653.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Irp9 protein of Yersinia enterocolitica participates in the synthesis of salicylate, the precursor of the siderophore yersiniabactin. In Pseudomonas species, salicylate synthesis is mediated by two enzymes: isochorismate synthase and isochorismate pyruvate-lyase. Both enzymes are required for complementation of a Yersinia irp9 mutant. However, irp9 is not able to complement Escherichia coli entC for the production of enterobactin, which requires isochorismate as a precursor. These results suggest that Irp9 directly converts chorismate into salicylate.

引用

收藏

页码：5648 / 5653

页数：6

相关论文

共 26 条

[1] Genetic organization of the yersiniabactin biosynthetic region and construction of avirulent mutants in Yersinia pestis [J].

Bearden, SW ;

Fetherston, JD ;

Perry, RD .

INFECTION AND IMMUNITY, 1997, 65 (05) :1659-1668

[2] Functional analysis of yersiniabactin transport genes of Yersinia enterocolitica [J].

Brem, D ;

Pelludat, C ;

Rakin, A ;

Jacobi, CA ;

Heesemann, J .

MICROBIOLOGY-SGM, 2001, 147 :1115-1127

[3] The high-pathogenicity island of Yersinia pseudotuberculosis can be inserted into any of the three chromosomal asn tRNA genes [J].

Buchrieser, C ;

Brosch, R ;

Bach, S ;

Guiyoule, A ;

Carniel, E .

MOLECULAR MICROBIOLOGY, 1998, 30 (05) :965-978

[4] Clustering of isochorismate synthase genes menF and entC and channeling of isochorismate in Escherichia coli [J].

Buss, K ;

Müller, R ;

Dahm, C ;

Gaitatzis, N ;

Skrzypczak-Pietraszek, E ;

Lohmann, S ;

Gassen, M ;

Leistner, E .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2001, 1522 (03) :151-157

[5] Characterization of a large chromosomal ''high-pathogenicity island'' in biotype 1B Yersinia enterocolitica [J].

Carniel, E ;

Guilvout, I ;

Prentice, M .

JOURNAL OF BACTERIOLOGY, 1996, 178 (23) :6743-6751

[6] MOLECULAR-CLONING, IRON-REGULATION AND MUTAGENESIS OF THE IRP2 GENE ENCODING HMWP2, A PROTEIN-SPECIFIC FOR THE HIGHLY PATHOGENIC YERSINIA [J].

CARNIEL, E ;

GUIYOULE, A ;

GUILVOUT, I ;

MERCEREAUPUIJALON, O .

MOLECULAR MICROBIOLOGY, 1992, 6 (03) :379-388

[7] Iron acquisition and metabolism by mycobacteria [J].

De Voss, JJ ;

Rutter, K ;

Schroeder, BG ;

Barry, CE .

JOURNAL OF BACTERIOLOGY, 1999, 181 (15) :4443-4451

[8] EVIDENCE OF IRON TRANSPORT ACTIVITY IN PASTEURELLA-MULTOCIDA CULTURES [J].

FLOSSMANN, KD ;

GRAJETZKI, C ;

ROSNER, H .

JOURNAL OF BASIC MICROBIOLOGY, 1985, 25 (09) :559-567

[9] Salicylate biosynthesis in Pseudomonas aeruginosa -: Purification and characterization of PchB, a novel bifunctional enzyme displaying isochorismate pyruvate-lyase and chorismate mutase activities [J].

Gaille, C ;

Kast, P ;

Haas, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (24) :21768-21775

[10]

GALAN JE, 1992, J BACTERIOL, V174, P4338