Five years on the wings of fork head

被引：574

作者：

Kaufmann, E ^{[1
]}

Knochel, W ^{[1
]}

机构：

[1] UNIV ULM,BIOCHEM ABT,D-89081 ULM,GERMANY

来源：

MECHANISMS OF DEVELOPMENT | 1996年 / 57卷 / 01期

关键词：

fork head; HNF-3; transcription factor;

D O I：

10.1016/0925-4773(96)00539-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Since its discovery five years ago the conserved family of fork head/HNF-3-related transcription factors has gained increasing importance for the analysis of gene regulatory mechanisms during embryonic development and in differentiated cells. Different members of this family, which is defined by a conserved 110 amino acid residues encompassing DNA binding domain of winged helix structure, serve as regulatory keys in embryogenesis, in tumorigenesis or in the maintenance of differentiated cell states. The purpose of this review is to summarize the accumulating amount of data on structure, expression and function of fork head/HNF-3-related transcription factors.

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收藏

页码：3 / 20

页数：18

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