Protein-mediated base flipping

被引：18

作者：

Hornby, DP ^{[1
]}

Ford, GC ^{[1
]}

机构：

[1] Univ Sheffield, Dept Mol Biol, Krebs Inst Biomol Res, Sheffield S10 2TN, S Yorkshire, England

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1998年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0958-1669(98)80007-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the discovery that the DNA methyltransferase M.Hhal utilises a base flipping mechanism to expose its target cytosine during catalysis, this phenomenon has been observed in other nucleic acid modifying enzymes. The crystallographic analyses of such enzyme-DNA complexes have revealed the molecular features of extrahelical base stabilisation, but have been less informative about the flipping process itself.

引用

页码：354 / 358

页数：5

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