Only the N-terminal domain of FtsK functions in cell division

被引：116

作者：

Draper, GC ^{[1
]}

McLennan, N ^{[1
]}

Begg, K ^{[1
]}

Masters, M ^{[1
]}

Donachie, WD ^{[1
]}

机构：

[1] Univ Edinburgh, Inst Cell & Mol Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

JOURNAL OF BACTERIOLOGY | 1998年 / 180卷 / 17期

关键词：

D O I：

10.1128/JB.180.17.4621-4627.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Deletion of ftsK results in the inhibition of cell division, but this inhibition can be reversed by a plasmid carrying only the first similar to 17% of ftsK. The division block can be suppressed in most mutants by deletion of dacA, which codes for the D-alanine:D-alanine carboxypeptidase PBP5, or in all mutants by overexpression of ftsN. Overexpression of ftsK inhibits cell division and the formation of FtsZ rings. This division block is not due to the induction of either the SOS or the heat shock regulons.

引用

页码：4621 / 4627

页数：7

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