In vivo degradation of poly(DTE carbonate) membranes.: Analysis of the tissue reactions and mechanical properties

被引：10

作者：

Asikainen, Antti J. ^{[1
,4
]}

Pelto, Mika ^{[3
]}

Noponen, Jukka ^{[1
]}

Kellomaki, Minna ^{[3
]}

Pihlajamaki, Harri ^{[4
]}

Lindqvist, Christian ^{[1
,2
]}

Suuronen, Riitta ^{[5
,6
]}

机构：

[1] Univ Helsinki, Dept Oral & Maxillofacial Surg, Helsinki, Finland

[2] Helsinki Univ Cent Hosp, Dept Oral & Maxillofacial Surg, Helsinki, Finland

[3] Tampere Univ Technol, Inst Biomat, FIN-33101 Tampere, Finland

[4] Cent Mil Hosp, Res Inst Mil Med, Helsinki, Finland

[5] Tampere Univ, Inst Regenerat Med, FIN-33101 Tampere, Finland

[6] Tampere Univ Hosp, Inst Regenerat Med, FIN-33101 Tampere, Finland

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2008年 / 19卷 / 01期

关键词：

Biopolymers - Biosorption - Calcification (biochemistry) - Degradation - Mechanical properties - Reaction rates;

D O I：

10.1007/s10856-007-3134-2

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

Different bioabsorbable polymers and their co-polymers have been used to construct an optimal material for guided bone regeneration applications. Our aim was to evaluate a novel bioabsorbable material in a soft tissue environment. In this study, a poly(DTE carbonate) membrane (0.2-0.3 mm) was implanted into 20 NZW rabbits' subcutaneous pouches for 6, 12, 24 and 52 weeks. The material was evaluated by means of histological reactions to the material and mechanical properties of the membrane. Based on this study, it can be concluded that poly(DTE carbonate) elicited a very modest foreign body reaction in the soft tissues. This reaction was uniform throughout the study. Varying amounts of calcification was seen in the fibrous capsule surrounding the implant. The number of calcified bodies did not correlate to healing time.

引用

页码：53 / 58

页数：6

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