Fast tomographic reconstruction on multicore computers

被引:179
作者
Agulleiro, J. I. [2 ]
Fernandez, J. J. [1 ]
机构
[1] Natl Res Council CSIC, Natl Biotechnol Ctr, Madrid 28049, Spain
[2] Univ Almeria, Supercomp & Algorithms Grp, Almeria 04120, Spain
关键词
D O I
10.1093/bioinformatics/btq692
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Tomo3D implements a multithreaded vectorized approach to tomographic reconstruction that takes full advantage of the computer power in modern multicore computers. Full resolution tomograms are generated at high speed on standard computers with no special system requirements. Tomo3D has the most common reconstruction methods implemented, namely weighted Back-projection (WBP) and simultaneous iterative reconstruction technique (SIRT). It proves to be competitive with current graphic processor unit solutions in terms of processing time, in the order of a few seconds with WBP or minutes with SIRT. The program is compatible with standard packages, which easily allows integration in the electron tomography workflow.
引用
收藏
页码:582 / 583
页数:2
相关论文
共 10 条
[1]   Vectorization with SIMD extensions speeds up reconstruction in electron tomography [J].
Agulleiro, J. I. ;
Garzon, E. M. ;
Garcia, I. ;
Fernandez, J. J. .
JOURNAL OF STRUCTURAL BIOLOGY, 2010, 170 (03) :570-575
[2]   Implementation and performance evaluation of reconstruction algorithms on graphics processors [J].
Diez, Daniel Castano ;
Mueller, Hannes ;
Frangakis, Achilleas S. .
JOURNAL OF STRUCTURAL BIOLOGY, 2007, 157 (01) :288-295
[3]   High performance computing in structural determination by electron cryomicroscopy [J].
Fernandez, J. J. .
JOURNAL OF STRUCTURAL BIOLOGY, 2008, 164 (01) :1-6
[4]   A Review of SIMD Multimedia Extensions and their Usage in Scientific and Engineering Applications [J].
Hassaballah, M. ;
Omran, Saleh ;
Mahdy, Youssef B. .
COMPUTER JOURNAL, 2008, 51 (06) :630-649
[5]  
Hennessy J., 2007, Computer Architecture-A Quantitative Approach
[6]   Structural studies by electron tomography:: From cells to molecules [J].
Lucic, V ;
Förster, F ;
Baumeister, W .
ANNUAL REVIEW OF BIOCHEMISTRY, 2005, 74 :833-865
[7]   A matrix approach to tomographic reconstruction and its implementation on GPUs [J].
Vazquez, F. ;
Garzon, E. M. ;
Fernandez, J. J. .
JOURNAL OF STRUCTURAL BIOLOGY, 2010, 170 (01) :146-151
[8]  
Wilkinson B., 2005, PARALLEL PROGRAMMING
[9]   High-performance iterative electron tomography reconstruction with long-object compensation using graphics processing units (GPUs) [J].
Xu, Wei ;
Xu, Fang ;
Jones, Mel ;
Keszthelyi, Bettina ;
Sedat, John ;
Agard, David ;
Mueller, Klaus .
JOURNAL OF STRUCTURAL BIOLOGY, 2010, 171 (02) :142-153
[10]   UCSF tomography: An integrated software suite for real-time electron microscopic tomographic data collection, alignment, and reconstruction [J].
Zheng, Shawn Q. ;
Keszthelyi, Bettina ;
Branlund, Eric ;
Lyle, John M. ;
Braunfeld, Michael B. ;
Sedat, John W. ;
Agard, David A. .
JOURNAL OF STRUCTURAL BIOLOGY, 2007, 157 (01) :138-147