Cell therapy in Parkinson's disease -: stop or go?

被引:174
作者
Dunnett, SB [1 ]
Björklund, A
Lindvall, O
机构
[1] Cardiff Univ, Sch Biosci, Cardiff CF10 3US, S Glam, Wales
[2] Lund Univ, Wallenberg Neurosci Ctr, S-22184 Lund, Sweden
关键词
D O I
10.1038/35072572
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The results of the first double-blind placebo-controlled trial using grafts of embryonic tissue to treat Parkinson's disease have aroused widespread interest and debate about the future of cell replacement therapies. What are the key issues that need to be resolved and the directions in which this technology is likely to develop?. © 2001 Macmillan Magazines Ltd.
引用
收藏
页码:365 / 369
页数:5
相关论文
共 59 条
  • [1] ANNETT LE, 1995, EXP BRAIN RES, V103, P355
  • [2] [Anonymous], ADV CELLULAR NEUROBI
  • [3] TRANSPLANTATION OF ADRENAL-MEDULLARY TISSUE TO STRIATUM IN PARKINSONISM - 1ST CLINICAL-TRIALS
    BACKLUND, EO
    GRANBERG, PO
    HAMBERGER, B
    KNUTSSON, E
    MARTENSSON, A
    SEDVALL, G
    SEIGER, A
    OLSON, L
    [J]. JOURNAL OF NEUROSURGERY, 1985, 62 (02) : 169 - 173
  • [4] RE-INNERVATION OF THE DENERVATED STRIATUM BY SUBSTANTIA NIGRA TRANSPLANTS - FUNCTIONAL CONSEQUENCES AS REVEALED BY PHARMACOLOGICAL AND SENSORIMOTOR TESTING
    BJORKLUND, A
    DUNNETT, SB
    STENEVI, U
    LEWIS, ME
    IVERSEN, SD
    [J]. BRAIN RESEARCH, 1980, 199 (02) : 307 - 333
  • [5] RECONSTRUCTION OF THE NIGROSTRIATAL DOPAMINE PATHWAY BY INTRA-CEREBRAL NIGRAL TRANSPLANTS
    BJORKLUND, A
    STENEVI, U
    [J]. BRAIN RESEARCH, 1979, 177 (03) : 555 - 560
  • [6] BJORKLUND A, 1980, CELL TISSUE RES, V212, P39
  • [7] ETHICAL GUIDELINES FOR THE USE OF HUMAN EMBRYONIC OR FETAL TISSUE FOR EXPERIMENTAL AND CLINICAL NEUROTRANSPLANTATION AND RESEARCH
    BOER, GJ
    [J]. JOURNAL OF NEUROLOGY, 1994, 242 (01) : 1 - 13
  • [8] Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease
    Brundin, P
    Pogarell, O
    Hagell, P
    Piccini, P
    Widner, H
    Schrag, A
    Kupsch, A
    Crabb, L
    Odin, P
    Gustavii, B
    Björklund, A
    Brooks, DJ
    Marsden, CD
    Oertel, WH
    Quinn, NP
    Rehncrona, S
    Lindvall, O
    [J]. BRAIN, 2000, 123 : 1380 - 1390
  • [9] Improving the survival of grafted dopaminergic neurons:: A review over current approaches
    Brundin, P
    Karlsson, J
    Emgård, M
    Schierle, GSK
    Hansson, O
    Petersén, Å
    Castilho, RF
    [J]. CELL TRANSPLANTATION, 2000, 9 (02) : 179 - 195
  • [10] Brundin P, 1992, NEURAL TRANSPLANTATI, P139