JAK3 Specific Kinase Inhibitors: When Specificity Is Not Enough

被引：15

作者：

Cox, Luk ^{[1
,2
]}

Cools, Jan ^{[1
,2
]}

机构：

[1] VIB, Dept Mol & Dev Genet, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

来源：

CHEMISTRY & BIOLOGY | 2011年 / 18卷 / 03期

关键词：

JANUS KINASES; SELECTIVITY;

D O I：

10.1016/j.chembiol.2011.03.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Janus kinases are important signaling proteins implicated in cytokine signaling. In particular, Janus kinase 3 (JAK3) has gained attention as a target for inhibition of the immune system, due to its importance for T and B cell development and function. In this issue however, Haan et al. (2011) show that inhibition of JAK3 activity may not be sufficient for this purpose.

引用

页码：277 / 278

页数：2

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