From the thymus to longevity in the periphery

被引：19

作者：

Wakim, Linda M. ^{[1
]}

Bevan, Michael J. ^{[1
]}

机构：

[1] Univ Washington, Howard Hughes Med Inst, Dept Immunol, Seattle, WA 98195 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 03期

关键词：

CD8(+) T-CELLS; TRANSCRIPTIONAL REPRESSOR BLIMP-1; HERPES-SIMPLEX-VIRUS; NONLYMPHOID TISSUE; MEMORY CELLS; EFFECTOR; INFECTION; HOMEOSTASIS; RESPONSES; SUBSETS;

D O I：

10.1016/j.coi.2010.03.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An important attribute of the adaptive immune system is the ability to remember a prior encounter with a pathogen; an ability termed immunological memory. Bigger, better, and stronger responses are mounted upon a secondary encounter with the pathogen potentially resulting in clearance of the infection before the development of disease. We will review recent advances in the field of memory CD8(+) T cell differentiation focusing on both intrinsic and extrinsic factors that govern the development of T cell memory.

引用

页码：274 / 278

页数：5

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