The application of PEDRI to the study of free radicals in vivo

被引：19

作者：

Foster, MA ^{[1
]}

Seimenis, I ^{[1
]}

Lurie, DJ ^{[1
]}

机构：

[1] Univ Aberdeen, Dept Biomed Phys & Bioengn, Aberdeen AB25 2ZD, Scotland

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 1998年 / 43卷 / 07期

关键词：

D O I：

10.1088/0031-9155/43/7/010

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Proton-electron double-resonance imaging (PEDRI) has considerable value for study of the distribution and elimination pathways of nitroxide foe radicals (NFRs). This has been illustrated by its use in studies of kidney function in the living rat in which the NFR proxyl carboxylic acid (PCA) has been employed as a 'tracer'. The technique, at its present stage of development, can demonstrate location of PCA in enough detail to observe the passage through kidney cortex and medulla differentially, and to see the NFR within the major abdominal blood vessels. These studies are helping towards an understanding of the metabolic fate of PCA, as well as providing information about kidney performance after challenge with a nephrotoxin. In addition, nitric oxide complexes, formed in vivo by providing rats with a nitrite-rich diet, have been observed ex vivo using PEDRI and field-cycled DNP.

引用

页码：1893 / 1897

页数：5

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