Combined analysis of language tasks in fMRI improves assessment of hemispheric dominance for language functions in individual subjects

被引:124
作者
Ramsey, NF [1 ]
Sommer, IEC [1 ]
Rutten, GJ [1 ]
Kahn, RS [1 ]
机构
[1] Univ Utrecht, Med Ctr, Dept Psychiat, NL-3584 CX Utrecht, Netherlands
关键词
D O I
10.1006/nimg.2000.0722
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent advances in functional neuroimaging techniques have prompted an increase in the number of studies investigating lateralization of language functions. One of the problems in relating findings of various studies to one another is the diversity of reported results. This may be due to differences in the tasks that are used to stimulate language processing regions and in the control tasks, as well as differences in the way imaging data are analyzed, in particular the threshold for significance of signal change. We present a simple method to assess language lateralization that allows for some variation of tasks and statistical thresholding, but at the same time yields reliable and reproducible results. Images acquired during a set of word-comprehension and -production tasks are analyzed conjointly. As opposed to the use of any one particular task, this combined task analysis (CTA) approach is geared toward identifying language regions that are involved in generic language functions rather than regions that are involved in functions that are specific to a single task. In two experiments CTA is compared to single-task analysis in healthy right-handed males. In a third experiment left-handed males were examined. Results indicate that CTA: (1) improves detection of language-related brain activity in individual subjects and (2) yields a high language laterality index (LI) in right-handed males with a small variance across subjects. The high LI matches the strong left-hemisphere dominance for language that is typical for these subjects as reported in neuropsychological and clinical tests in other studies. In the left-handed subjects dominance was found either in the left (n = 4) or the right (n = 1) hemisphere or was absent (n = 3). The LI derived from CTA is more consistent across statistical thresholds for significance of signal change in fMRI analysis than in individual-task analysis. Also, the CTA results are very similar to those obtained with conjunction analysis of the same data. (C) 2001 Academic Press.
引用
收藏
页码:719 / 733
页数:15
相关论文
共 85 条
[1]   DISTRIBUTED ANATOMY OF TRANSCORTICAL SENSORY APHASIA [J].
ALEXANDER, MP ;
HILTBRUNNER, B ;
FISCHER, RS .
ARCHIVES OF NEUROLOGY, 1989, 46 (08) :885-892
[2]   APHASIA SYNDROME OF STROKE IN THE LEFT ANTERIOR CEREBRAL-ARTERY TERRITORY [J].
ALEXANDER, MP ;
SCHMITT, MA .
ARCHIVES OF NEUROLOGY, 1980, 37 (02) :97-100
[3]   Handedness and cerebral dominance: The right shift theory [J].
Annett, M .
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 1998, 10 (04) :459-469
[4]   HANDEDNESS AND CEREBRAL REPRESENTATION OF SPEECH [J].
ANNETT, M .
ANNALS OF HUMAN BIOLOGY, 1976, 3 (04) :317-328
[5]  
[Anonymous], 1974, APHASISCHE SYMPTOMEN
[6]   Language dominance determined by whole brain functional MRI in patients with brain lesions [J].
Benson, RR ;
FitzGerald, DB ;
LeSueur, LL ;
Kennedy, DN ;
Kwong, KK ;
Buchbinder, BR ;
Davis, TL ;
Weisskoff, RM ;
Talavage, TM ;
Logan, WJ ;
Cosgrove, GR ;
Belliveau, JW ;
Rosen, BR .
NEUROLOGY, 1999, 52 (04) :798-809
[7]   Functional MRI localization of language in a 9-year-old child [J].
Benson, RR ;
Logan, WJ ;
Cosgrove, GR ;
Cole, AJ ;
Jiang, H ;
LeSueur, LL ;
Buchbinder, BR ;
Rosen, BR ;
Caviness, VS .
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1996, 23 (03) :213-219
[8]  
Binder JR, 1997, CLIN NEUROSCI, V4, P87
[9]   Determination of language dominance using functional MRI: A comparison with the Wada test [J].
Binder, JR ;
Swanson, SJ ;
Hammeke, TA ;
Morris, GL ;
Mueller, WM ;
Fischer, M ;
Benbadis, S ;
Frost, JA ;
Rao, SM ;
Haughton, VM .
NEUROLOGY, 1996, 46 (04) :978-984
[10]   LATERALIZED HUMAN BRAIN LANGUAGE SYSTEMS DEMONSTRATED BY TASK SUBTRACTION FUNCTIONAL MAGNETIC-RESONANCE-IMAGING [J].
BINDER, JR ;
RAO, SM ;
HAMMEKE, TA ;
FROST, JA ;
BANDETTINI, PA ;
JESMANOWICZ, A ;
HYDE, JS .
ARCHIVES OF NEUROLOGY, 1995, 52 (06) :593-601