The marginal Zone/Layer I as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex

被引:52
作者
Costa, Marcos R.
Kessaris, Nicoletta
Richardson, William D.
Goetz, Magdalena
Hedin-Pereira, Cecilia
机构
[1] Inst Stem Cell Res, Natl Res Ctr Environm & Hlth, D-85764 Neuherberg, Germany
[2] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
[3] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Dept Anat, Lab Neuroanat Celular, BR-21941 Rio De Janeiro, Brazil
[4] UCL, Wolfson Inst Biomed Res, Dept Biol, London WC1E 6BT, England
[5] Univ Munich, Inst Physiol, D-80336 Munich, Germany
基金
英国医学研究理事会;
关键词
marginal zone; cerebral cortex; development; neurogenesis; gliogenesis; Reelin; basement membrane;
D O I
10.1523/JNEUROSCI.2418-07.2007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The cellular diversity of the cerebral cortex is thought to arise from progenitors located in the ventricular zone and subventricular zone in the telencephalon. Here we describe a novel source of progenitors located outside these two major germinative zones of the mouse cerebral cortex that contributes to neurogenesis and gliogenesis. Proliferating cells first appear in the preplate of the embryonic cerebral cortex and further increase in the marginal zone during mid and late neurogenesis. The embryonic marginal zone progenitors differ in their molecular characteristics as well as the size and identity of their clonal progeny from progenitors isolated from the ventricular zone and subventricular zone. Time-lapse video microscopy and clonal analysis in vitro revealed that the marginal zone progenitor pool contains a large fraction of oligodendrocyte or astrocyte progenitors, as well as neuronal and bipotent progenitors. Thus, marginal zone progenitors are heterogenous in regard to their fate specification, as well as in regard to their region of origin (pallial and subpallial) as revealed by in vivo fate mapping. The local environment in the marginal zone tightly regulates the size of this novel progenitor pool, because both basement membrane defects in laminin gamma 1-/- mice or alterations in the cellular composition of the marginal zone in Pax6 Small Eye mutant mice lead to an increase in the marginal zone progenitor pool. In conclusion, we have identified a novel source of neuronal and glial progenitors in the marginal zone of the developing cerebral cortex with properties notably distinct from those of ventricular zone and subventricular zone progenitors.
引用
收藏
页码:11376 / 11388
页数:13
相关论文
共 85 条
[1]   For the long run: Maintaining germinal niches in the adult brain [J].
Alvarez-Buylla, A ;
Lim, DA .
NEURON, 2004, 41 (05) :683-686
[2]   Interneuron migration from basal forebrain to neocortex: Dependence on Dlx genes [J].
Anderson, SA ;
Eisenstat, DD ;
Shi, L ;
Rubenstein, JLR .
SCIENCE, 1997, 278 (5337) :474-476
[3]  
Ang ESBC, 2003, J NEUROSCI, V23, P5805
[4]   EMBRYONIC VERTEBRATE CENTRAL NERVOUS SYSTEM - REVISED TERMINOLOGY [J].
ANGEVINE, JB ;
BODIAN, D ;
COULOMBR.AJ ;
EDDS, MV ;
HAMBURGE.V ;
JACOBSON, M ;
LYSER, KM ;
PRESTIGE, MC ;
VARON, S ;
WEISS, PA .
ANATOMICAL RECORD, 1970, 166 (02) :257-&
[5]   Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons [J].
Belachew, S ;
Chittajallu, R ;
Aguirre, AA ;
Yuan, XQ ;
Kirby, M ;
Anderson, S ;
Gallo, V .
JOURNAL OF CELL BIOLOGY, 2003, 161 (01) :169-186
[6]   E1-Ngn2/Cre is a new line for regional activation of cre recombinase in the developing CNS [J].
Berger, J ;
Eckert, S ;
Scardigli, R ;
Guillemot, F ;
Gruss, P ;
Stoykova, A .
GENESIS, 2004, 40 (04) :195-199
[7]  
BERRY M, 1965, J ANAT, V99, P691
[8]  
Bishop KM, 2002, J NEUROSCI, V22, P7627
[9]   The first neurons of the human cerebral cortex [J].
Bystron, Irina ;
Rakic, Pasko ;
Molnar, Zoltan ;
Blakemore, Colin .
NATURE NEUROSCIENCE, 2006, 9 (07) :880-886
[10]   The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface [J].
Cappello, Silvia ;
Attardo, Alessio ;
Wu, Xunwei ;
Iwasato, Takuji ;
Itohara, Shigeyoshi ;
Wilsch-Braeuninger, Michaela ;
Eilken, Hanna M. ;
Rieger, Michael A. ;
Schroeder, Timm T. ;
Huttner, Wieland B. ;
Brakebusch, Cord ;
Goetz, Magdalena .
NATURE NEUROSCIENCE, 2006, 9 (09) :1099-1107