Organocatalytic asymmetric vinylogous addition to quinones -: formation of optically active α-aryl ketones

被引：69

作者：

Aleman, Jose ^{[1
]}

Jacobsen, Christian Borch ^{[1
]}

Frisch, Kim ^{[1
]}

Overgaard, Jacob ^{[1
]}

Jorgensen, Karl Anker ^{[1
]}

机构：

[1] Aarhus Univ, Dept Chem, Ctr Catalysis, DK-8000 Aarhus, Denmark

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 05期

关键词：

D O I：

10.1039/b716485h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first organocatalytic addition of dicyanoalkylidenes to quinones catalyzed by Cinchona alkaloids leading to formation of 1,4-diketone derivatives with high diastereomeric ratios ( up to >98 : <2 dr) and enantioselectivities ( up to 99% ee) has been developed; the optically active compounds obtained are useful for a number of transformations, e. g. the synthesis of optically active alpha-aryl ketones.

引用

页码：632 / 634

页数：3

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