Preclinical studies of alcohol binge drinking

被引:162
作者
Crabbe, John C. [1 ,2 ]
Harris, R. Adron [3 ]
Koob, George F. [4 ]
机构
[1] Oregon Hlth & Sci Univ, Portland Alcohol Res Ctr, Dept Behav Neurosci, Portland, OR 97201 USA
[2] VA Med Ctr, Portland, OR USA
[3] Univ Texas Austin, Waggoner Ctr Alcohol & Addict Res, Austin, TX 78712 USA
[4] Scripps Res Inst, Comm Neurobiol Addict Disorders, La Jolla, CA 92037 USA
来源
ADDICTION REVIEWS | 2011年 / 1216卷
关键词
binge drinking; alcohol; intoxication; animal models; CORTICOTROPIN-RELEASING-FACTOR; VOLUNTARY ETHANOL INTAKE; RECOMBINANT INBRED STRAINS; WITHDRAWAL-INDUCED ANXIETY; VENTRAL TEGMENTAL AREA; SPRAGUE-DAWLEY RATS; IN-THE-DARK; C57BL/6J MICE; DEPENDENT RATS; ADULT RATS;
D O I
10.1111/j.1749-6632.2010.05895.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
100404 [儿少卫生与妇幼保健学];
摘要
Binge drinking is prevalent and has serious biomedical consequences. In children, adolescents, and young adults, it is a prominent risk factor for later development of alcohol-use disorders. Many preclinical models have been employed to study the genetic risks for and biomedical consequences of alcohol drinking. However, these models historically did not result in blood-alcohol concentrations (BACs) exceeding 80 mg%; this relatively modest level is the threshold that currently defines a binge session, according to the NIAAA and CDC. Nevertheless, in alcohol-dependent rodents, binge drinking has been well documented. Key neurobiological substrates localized to brain reward and stress systems have been identified. Studies of newer models of binge drinking without dependence are reviewed here. In these models, rodents, non-human primates, and flies will drink enough to reach high BACs. They often display observable signs of intoxication. The neurobiological consequences of these episodes of binge drinking without dependence are reviewed, and preliminary evidence for roles for GABA, glutamate, opioid peptides, and corticotropin releasing factor are discussed, as is the need for more work to identify the antecedents and consequences of binge drinking in both animal models and humans.
引用
收藏
页码:24 / 40
页数:17
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