Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae)

被引：43

作者：

Dongmo, AB

Nguelefack, T

Lacaille-Dubois, MA

机构：

[1] Univ Bourgogne, Fac Pharm, Lab Pharmacognosie, Unite UMIB,UPRES EA 3360, F-21079 Dijon, France

[2] Univ Douala, Fac Sci, Lab Biol Organismes Anim, Douala, Cameroon

[3] Univ Dschang, Dept Biol & Physiol Anim, Dschang, Cameroon

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 98卷 / 1-2期

关键词：

Acacia pennata; Mimosaseae; flavonoids; antinociceptive activity; anti-inflammatory activity;

D O I：

10.1016/j.jep.2005.01.030

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The butanolic fraction of dried leaves of Acacia pennata (Mimosaceae) was tested for analgesic and anti-inflammatory activities in animal models. It showed significant protective effects against chemical stimuli (acetic acid and formalin) in the mouse. It also produced a significant increase of the threshold of sensitivity to pressure-induced pain in the rats. The extract revealed an inhibitory effect in carrageenin-induced rat paw oedema in the late phase. The results suggested that a peripheral mechanism is involved in the analgesic, associated to anti-inflammatory effect (NSAIDs-like). Among the class of compounds characterized in this fraction, flavonoids may be mainly responsible for the pharmacological activities. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：201 / 206

页数：6

共 33 条

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FLAVONOIDS AND RELATED-COMPOUNDS AS INHIBITORS OF ARACHIDONIC-ACID PEROXIDATION [J].