Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

被引：178

作者：

van Es, Michael A. ^{[1
]}

van Vught, Paul Wj ^{[1
]}

Blauw, Hylke M. ^{[1
]}

Franke, Lude ^{[2
]}

Saris, Christiaan G. J. ^{[1
]}

Van Den Bosch, Ludo ^{[3
]}

de Jong, Sonja W. ^{[1
]}

de Jong, Vianney ^{[4
]}

Baas, Frank ^{[5
,8
]}

van't Slot, Ruben ^{[2
]}

Lemmens, Robin

Schelhaas, Helenius J. ^{[6
]}

Birve, Anna ^{[7
]}

Sleegers, Kristel ^{[8
,9
]}

Van Broeckhoven, Christine ^{[9
]}

Schymick, Jennifer C. ^{[10
]}

Traynor, Bryan J. ^{[11
]}

Wokke, John H. J. ^{[1
]}

Wijmenga, Cisca ^{[2
,12
,14
]}

Robberecht, Wim ^{[3
]}

Andersen, Peter M.

Veldink, Jan H. ^{[1
]}

Ophoff, Roel A. ^{[13
,15
]}

van den Berg, Leonard H. ^{[1
]}

机构：

[1] Rudolf Magnus Inst Neurosci, Dept Neurol, Utrecht, Netherlands

[2] Univ Med Utrecht, Dept Biomed Genet, Complex Genet Sect, NL-3584 CX Utrecht, Netherlands

[3] Univ Hosp Gasthuisberg, Dept Neurol, B-3000 Louvain, Belgium

[4] Univ Amsterdam, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands

[5] Univ Amsterdam, Dept Neurogenet, NL-1105 AZ Amsterdam, Netherlands

[6] Univ Nijmegen, Med Ctr, Dept Neurol, NL-6525 GA Nijmegen, Netherlands

[7] Umea Univ Hosp, Inst Clin Neurosci, SE-90185 Umea, Sweden

[8] VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, B-2610 Antwerp, Belgium

[9] Univ Antwerp VIB, B-2610 Antwerp, Belgium

[10] NIA, Neurogenet Lab, Natl Inst Hlth, Bethesda, MD 20892 USA

[11] NIMH, Sect Dev Genet Epidemiol, Bethesda, MD 20892 USA

[12] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

[13] Univ Med Ctr Utrecht, Dept Med Genet, NL-3584 CX Utrecht, Netherlands

[14] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, NL-3584 CX Utrecht, Netherlands

[15] Univ Calif Los Angeles, Inst Neuropsychiat, Los Angeles, CA 90095 USA

来源：

NATURE GENETICS | 2008年 / 40卷 / 01期

关键词：

D O I：

10.1038/ng.2007.52

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04x10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18 - 1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.

引用

页码：29 / 31

页数：3

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