A Trinuclear Oxo-Chromium(III) Complex Containing the Natural Flavonoid Primuletin: Synthesis, Characterization, and Antiradical Properties

被引：15

作者：

Alexiou, Anamaria D. P. ^{[1
]}

Decandio, Carla C. ^{[1
]}

Almeida, Sabrina da N. ^{[1
]}

Ferreira, Marcelo J. P. ^{[2
]}

Romoff, Paulete ^{[1
]}

Rocha, Reginaldo C. ^{[3
]}

机构：

[1] Univ Presbiteriana Mackenzie, Escola Engn, BR-01302000 Sao Paulo, SP, Brazil

[2] Univ Sao Paulo, Inst Biociencias, Dept Bot, BR-05508090 Sao Paulo, SP, Brazil

[3] Los Alamos Natl Lab, Los Alamos, NM 87545 USA

来源：

MOLECULES | 2015年 / 20卷 / 04期

关键词：

antiradical activity; chromium(III) complexes; flavonoids; metal-oxo cluster; primuletin; ANTIOXIDANT;

D O I：

10.3390/molecules20046310

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A new trinuclear oxo-centered chromium(III) complex with formula [Cr3O(CH3CO2)(6)(L)(H2O)(2)] (L = 5-hydroxyflavone, known as primuletin) was synthetized and characterized by ESI mass spectrometry, thermogravimetry, and H-1-NMR, UV-Vis, and FTIR spectroscopies. In agreement with the experimental results, DFT calculations indicated that the flavonoid ligand is coordinated to one of the three Cr(III) centers in an O,O-bidentate mode through the 5-hydroxy/4-keto groups. In a comparative study involving the uncoordinated primuletin and its corresponding complex, systematic reactions with the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that antiradical activity increases upon complexation.

引用

页码：6310 / 6318

页数：9

共 21 条

[1]

Enhancement of antioxidant and anti-inflammatory activities of bioflavonoid rutin by complexation with transition metals [J].

Afanas'ev, IB ;

Ostrakhovitch, EA ;

Mikhal'chik, EV ;

Ibragimova, GA ;

Korkina, LG .

BIOCHEMICAL PHARMACOLOGY, 2001, 61 (06) :677-684

[2]

Andersen O. M., 2006, FLAVONOIDS CHEM BIOC

[3]

[Anonymous], REDOX REP, DOI DOI 10.1179/13510000422500389715231064

[4]

[Anonymous], THESIS U SAO PAULO S

[5]

[Anonymous], SYSTEMATIC INVESTIGA

[6]

Crystal structures of the isomorphous prototypic oxo-centered trinuclear complexes [Cr3O(OOCCH3)(6)(H2O)(3)]Cl center dot 6H(2)O and [Fe3O(OOCCH3)(6)(H2O)(3)]Cl center dot 6H(2)O [J].

Anson, CE ;

Bourke, JP ;

Cannon, RD ;

Jayasooriya, UA ;

Molinier, M ;

Powell, AK .

INORGANIC CHEMISTRY, 1997, 36 (06) :1265-+

[7]

CHEMICAL AND PHYSICAL-PROPERTIES OF TRIANGULAR BRIDGED METAL-COMPLEXES [J].

CANNON, RD ;

WHITE, RP .

PROGRESS IN INORGANIC CHEMISTRY, 1988, 36 :195-298

[8]

Breakdown kinetics of the tri-chromium(III) oxo acetate cluster ([Cr3O(OAc)6]+) with some ligands of biological interest [J].

Chaudhary, Shveta ;

Van Horn, J. David .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2007, 101 (02) :329-335

[9]

Antioxidant property of quercetin-Cr(III) complex: The role of Cr(III) ion [J].

Chen, Weijun ;

Sun, Shaofang ;

Cao, Wei ;

Liang, Yan ;

Song, Jirong .

JOURNAL OF MOLECULAR STRUCTURE, 2009, 918 (1-3) :194-197

[10]

Frisch M. J., 2016, Gaussian 03 Revision B.03

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