Molecular epidemiology of HIV type 1 subtypes in Equatorial Guinea

被引：19

作者：

Ortiz, M

Sanchez, I

Gonzalez, MP

León, MI

Abeso, N

Asumu, E

García-Sáiz, A

机构：

[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Serv Diagnost & Referencia Retrovirus, Madrid 28220, Spain

[2] Inst Salud Carlos III, Escuela Nacl Sanidad, Dept Salud Int, Madrid, Spain

[3] Program SIDA ETS, Minsab, Guinea

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2001年 / 17卷 / 09期

关键词：

D O I：

10.1089/088922201750252043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Equatorial Guinea is endemic for HIV-1. This country borders to the north with Cameroon, where different subtypes belonging to group M, as well as group O strains, are circulating simultaneously. To assess the molecular epidemiology of HIV-1 in Equatorial Guinea we analyzed 76 plasma samples collected throughout 1999 from seropositive individuals. Phylogenetic analysis of the gp41 region revealed that 53 were of subtype A, with 64% of these sequences clustering with CRF02_AG reference strains; 11 were of subtype C; 4 were of subtype D; 2 (closely related to subtype F2) were of subtype F; 3 were of subtype G, two of them forming a separate cluster with the recombinant circulating forms CRF06_cpx; 1 was of subtype H; and 2 were unclassifiable. Although subtype A is predominant, the presence of 14% of subtype C is also noteworthy. This work represents the first HIV-1 subtype distribution study in Equatorial Guinea.

引用

页码：851 / 855

页数：5

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