Nociceptive processing in the human brain

被引:188
作者
Tracey, I
机构
[1] Univ Oxford, Dept Human Anat & Genet, Pain Imaging Neurosci Grp, Oxford OX1 3QX, England
[2] Univ Oxford, Ctr Funct Magnet Resonance Imaging Brain, Oxford OX1 3QX, England
关键词
D O I
10.1016/j.conb.2005.06.010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Since the advent of modern neuroimaging techniques, studies have been carried out to examine nociceptive processing within the human brain non-invasively. Combined with advances in immunohistochemistry, histology and genetics, we have been able to correlate more objective measures of nociceptive processing with the subjective experience that is pain. The result has produced a dramatic shift in our thinking about the neural circuitry involved in nociceptive processing, revealing that pain is much more than a submodality of the sense of touch.
引用
收藏
页码:478 / 487
页数:10
相关论文
共 68 条
[1]   DIENCEPHALIC MECHANISMS OF PAIN SENSATION [J].
ALBEFESSARD, D ;
BERKLEY, KJ ;
KRUGER, L ;
RALSTON, HJ ;
WILLIS, WD .
BRAIN RESEARCH REVIEWS, 1985, 9 (03) :217-296
[2]   Human brain mechanisms of pain perception and regulation in health and disease [J].
Apkarian, AV ;
Bushnell, MC ;
Treede, RD ;
Zubieta, JK .
EUROPEAN JOURNAL OF PAIN, 2005, 9 (04) :463-484
[3]   Chronic back pain is associated with decreased prefrontal and thalamic gray matter density [J].
Apkarian, AV ;
Sosa, Y ;
Sonty, S ;
Levy, RM ;
Harden, RN ;
Parrish, TB ;
Gitelman, DR .
JOURNAL OF NEUROSCIENCE, 2004, 24 (46) :10410-10415
[4]   Differential effects on the laser evoked potential of selectively attending to pain localisation versus pain unpleasantness [J].
Bentley, DE ;
Watson, A ;
Treede, RD ;
Barrett, G ;
Youell, PD ;
Kulkarni, B ;
Jones, AKP .
CLINICAL NEUROPHYSIOLOGY, 2004, 115 (08) :1846-1856
[5]   Somatotopic representation of nociceptive information in the putamen:: An event-related fMRI study [J].
Bingel, U ;
Gläscher, J ;
Weiller, C ;
Büchel, C .
CEREBRAL CORTEX, 2004, 14 (12) :1340-1345
[6]   Somatotopic organization of human somatosensory cortices for pain:: a single trial fMRI study [J].
Bingel, U ;
Lorenz, J ;
Glauche, V ;
Knab, R ;
Gläscher, J ;
Weiller, C ;
Büchel, C .
NEUROIMAGE, 2004, 23 (01) :224-232
[7]   FMRI measurement of CNS responses to naloxone infusion and subsequent mild noxious thermal stimuli in healthy volunteers [J].
Borras, MC ;
Becerra, L ;
Ploghaus, A ;
Gostic, JM ;
DaSilva, A ;
Gonzalez, RG ;
Borsook, D .
JOURNAL OF NEUROPHYSIOLOGY, 2004, 91 (06) :2723-2733
[8]   rTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study [J].
Brighina, F ;
Piazza, A ;
Vitello, G ;
Aloisio, A ;
Palermo, A ;
Daniele, O ;
Fierro, B .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2004, 227 (01) :67-71
[9]   From nociception to pain perception: imaging the spinal and supraspinal pathways [J].
Brooks, J ;
Tracey, I .
JOURNAL OF ANATOMY, 2005, 207 (01) :19-33
[10]   Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging [J].
Brooks, JCW ;
Zambreanu, L ;
Godinez, A ;
Craig, AD ;
Tracey, I .
NEUROIMAGE, 2005, 27 (01) :201-209