Cytogenetic changes in two cases of subependymal giant-cell astrocytoma

被引：11

作者：

Debiec-Rychter, M

Jesionek-Kupnicka, D

Zakrzewski, K

Liberski, PP

机构：

[1] Med Sch Lodz, Chair Oncol, Lab Tumor Biol, PL-93509 Lodz, Poland

[2] Med Sch Lodz, Chair Oncol, Dept Tumor Pathol, Lodz, Poland

[3] Polish Mother Mem Hosp, Dept Pediat Neurosurg, Lodz, Poland

来源：

CANCER GENETICS AND CYTOGENETICS | 1999年 / 109卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(98)00140-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic analysis of subependymal giant-cell astrocytomas (SEGAs) from two patients presenting the clinical symptoms of tuberous sclerosis complex (TSC) revealed clonal chromosomal changes, resulting in the partial loss of chromosome 22q in both tumors. Immunohistochemically, tumors exhibited features of glial differentiation, while ultrastructural studies identified the characteristic paracrystalline inclusions within the tumor cells. To our knowledge, it is the first cytogenetic description of SEGAs associated with TSC. (C) Elsevier Science Inc., 1999. All rights reserved.

引用

页码：29 / 33

页数：5

共 26 条

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